Arterial Spin-Labeling Magnetic Resonance Imaging After Revascularization of Moyamoya Disease
Arterial Spin-Labeling Magnetic Resonance Imaging After Revascularization of Moyamoya Disease
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DOI：
10.1016/j.jstrokecerebrovasdis.2012.05.010
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发表时间：
2013-08-01
影响因子：
2.5
通讯作者：
Mikuni, Nobuhiro
中科院分区：
文献类型：
--
作者：
Sugino, Toshiya;Mikami, Takeshi;Mikuni, Nobuhiro
动脉自旋标记（ASL）磁共振成像（MRI）是一种在无造影剂的情况下描绘脑灌注的技术。本研究的目的是确定ASL是否可用于检测烟雾病血运重建后的过度灌注，与N-异丙基-[123 I] β-碘苯丙胺（I-123-IMP）单光子发射计算机断层扫描（SPECT）一样有效。15例烟雾病患者被纳入研究。所有患者均接受了手术血运重建。术后急性期分别用FAIR ASL和123-IMP SPECT测定局部脑血流量（rCBF），并比较术侧与对侧的rCBF。然后根据使用每种模式测量的rCBF计算不对称比（AR）。ASL的术后AR与I-123-IMP SPECT的术后AR中度相关（y = 0.180 x 10.819; R = 0.80; P = .0003）。在该系列中，2例患者（13.3%）在血运重建后出现症状性过度灌注，因此显示ASL的AR增加。我们的数据表明，在血运重建后，使用FAIR ASL补充I-123-IMP SPECT可以检测到过度灌注患者的rCBF早期增加。我们的数据表明，FAIR ASL是一种方便的方法，可以重复进行，而不使用造影剂或放射性同位素的评价过度灌注。
Arterial spin labeling (ASL) magnetic resonance imaging (MRI) is a technique for depicting cerebral perfusion without contrast medium. The purpose of this study was to determine whether ASL can be used to detect hyperperfusion after revascularization for moyamoya disease as effectively as N-isopropyl-[123I]beta-iodoamphetamine (I-123-IMP) single-photon emission computed tomography (SPECT). Fifteen consecutive patients with moyamoya disease were included in the study. All patients underwent surgical revascularization. Postoperatively, regional cerebral blood flow (rCBF) was measured by flow-sensitive alternating inversion recovery (FAIR) ASL and I-123-IMP SPECT during the acute stage, and rCBF of the operative side was compared with the other side. The asymmetry ratio (AR) was then calculated from the rCBF as measured using each modality. The postoperative AR of ASL was moderately correlated with that of I-123-IMP SPECT (y = 0.180x 1 0.819; R = 0.80; P = .0003). In this series, 2 patients (13.3%) suffered symptomatic hyperperfusion after revascularization and accordingly exhibited increased AR of ASL. Our data indicate that early increases in rCBF in patients with hyperperfusion could be detected using FAIR ASL supplemental to I-123-IMP SPECT after revascularization. Our data indicate that FAIR ASL is a convenient method for evaluating hyperperfusion that can be performed repeatedly without the use of contrast medium or radioisotopes.