Effect of soda consumption on urinary stone risk parameters.
Effect of soda consumption on urinary stone risk parameters.
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苏打水消耗对尿路结石风险参数的影响。
DOI：
10.1089/end.2008.0225
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发表时间：
2009
影响因子：
2.7
通讯作者：
Assimos,DeanG
中科院分区：
文献类型：
--
作者：
Passman,CoreyM;Holmes,RossP;Knight,John;Easter,Linda;Pais,Vernon;Assimos,DeanG
背景和目的：液体消耗已被证明影响肾结石的形成。研究表明，饮用可乐可能是结石病的危险因素，而含有柠檬酸的液体可能会减弱结石的活动。然而，在这些研究中并不总是控制饮食。我们进行了一项研究，以确定三种不同的液体对尿路结石的危险因素的影响。主题和方法：六个健康的非结石形成的成年人被放置在一个标准化的代谢饮食和消耗三种不同类型的流体在三个5天的期间。每个序列之间有2天的洗脱期。在这些期间给予的三种液体是Le Bleu®水、不含咖啡因的健怡可乐®和Fresca®（含柠檬酸盐）。选择这两种苏打制剂是为了防止碳水化合物和咖啡因促进钙排泄的已知增加。在每个序列的第4天和第5天收集24小时尿液样本。测量以下尿液参数：容量、钙、草酸盐、肌酐、尿酸、柠檬酸盐、钠、镁、磷、硫酸盐、尿素氮、pH值和过饱和指数。结果：与自选饮食方案相比，尿量显著增加，草酸钙过饱和度显著降低。在Fresca队列中也观察到尿酸降低。有没有统计学上的显着差异，任何的尿液parameters.Conclusion：有没有增加的风险或利益，消费Fresca或无咖啡因的健怡可乐相比，与蓝带瓶装水方面的结石形成。
Background and Purpose:Fluid consumption has been demonstrated to influence kidney stone formation. Studies have shown that consumption of cola may be a risk factor for stone disease, while fluids containing citric acid may attenuate stone activity. Diet was not always controlled in these investigations, however. We undertook a study to determine the impact of three different fluids on urinary stone risk factors.Subjects and Methods:Six healthy nonstone-forming adults were placed on a standardized metabolic diet and consumed three different types of fluid during three 5-day periods. There was a 2-day washout between each sequence. The three fluids administered during these periods were Le Bleu®water, caffeine-free Diet Coke,®and Fresca®(citrate containing). These two soda preparations were chosen to prevent the known increase in calcium excretion promoted by carbohydrates and caffeine. Twenty-four hour urine specimens were collected on days 4 and 5 of each sequence. The following urinary parameters were measured: Volume, calcium, oxalate, creatinine, uric acid, citrate, sodium, magnesium, phosphorus, sulfate, urea nitrogen, pH, and supersaturation indices. A pairedttest was used for statistical analysis.Results:Urinary volumes were significantly higher and supersaturation of calcium oxalate significantly lower compared with a self-selected dietary regimen. A decrease in uric acid was also seen in the Fresca cohort. There were no statistically significant differences for any of the urinary parameters.Conclusion:There is no increased risk or benefit to consuming Fresca or caffeine-free Diet Coke compared with Le Bleu bottled water with respect to stone formation.