Association of single nucleotide polymorphisms in secreted frizzled‐related protein 1 gene with bone mineral density in Japanese women
Association of single nucleotide polymorphisms in secreted frizzled‐related protein 1 gene with bone mineral density in Japanese women
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DOI：
10.1111/j.1447-0594.2009.00540.x
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发表时间：
2009-09
影响因子：
3.3
通讯作者：
K. Ohnaka;Ken Yamamoto;Kenjiro Nakamura;M. Adachi;H. Kawate;S. Kono;R. Takayanagi
中科院分区：
文献类型：
--
作者：
K. Ohnaka;Ken Yamamoto;Kenjiro Nakamura;M. Adachi;H. Kawate;S. Kono;R. Takayanagi
目的：近年来研究表明Wnt信号通路在骨代谢中起重要作用。本研究的目的是通过关联研究探讨Wnt拮抗剂分泌卷曲相关蛋白1 （SFRP1）基因是否参与骨质疏松症的病因学。
Aim: Recent studies have demonstrated that the Wnt signaling pathway plays an important role in bone metabolism. The purpose of this study was to examine whether the gene of secreted frizzled‐related protein 1 (SFRP1), a Wnt antagonist, is involved in the etiology of osteoporosis using association study.