Metal-Ligand Multiple Bonds
Metal-Ligand Multiple Bonds
复制标题
DOI：
10.1021/om00114a601
复制
发表时间：
1989-12
期刊：
影响因子：
2.8
通讯作者：
Eric Maatta
中科院分区：
文献类型：
--
作者：
Eric Maatta
氧化物可能是最常见的多重键配体。在生物学中，人们的注意力转向了铁和铜氧化物作为各种酶的活性中间体的作用，这些酶利用分子氧氧化底物。最显著的例子是细胞色素P450，这是一种在大多数生物体中普遍存在的氧化剂。在人类中，细胞色素P450存在于多种组织中，由于多种原因将氧原子结合到小分子中。细胞色素P450的一个有趣用途是作为肝脏中的解毒剂，它将脂溶性化合物中的C-H键转化为C-OH基团（醇），然后可以通过肾脏和泌尿系统排出体外。参与破坏碳氢键的活性中间体似乎是末端氧化铁，Fe=O。
Oxides may be the most common multiply-bonded ligand. In biology, attention has turned to the role of iron and copper oxides as active intermediates in a variety of enzymes that use molecular oxygen to oxidize substrates. The most notable example is cytochrome P450, a ubiquitous class of oxidizing agents found in most organisms. In humans, cytochrome P450 is found in a variety of tissues, incorporating oxygen atoms into small molecules for a plethora of reasons. One interesting use of cytochrome P450 is as a detoxifying agent in the liver, where it converts C-H bonds in fat-soluble compounds into C-OH groups (alcohols), which can then be excreted via the kidneys and urinary system. The active intermediate involved in breaking the C-H bond appears to be a terminal iron oxide, Fe=O.