OBSERVATION OF CARDIAC LIPIDS IN HUMANS BY LOCALIZED H-1 MAGNETIC-RESONANCE SPECTROSCOPIC IMAGING
OBSERVATION OF CARDIAC LIPIDS IN HUMANS BY LOCALIZED H-1 MAGNETIC-RESONANCE SPECTROSCOPIC IMAGING
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DOI：
10.1002/mrm.1910320205
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发表时间：
1994-08-01
影响因子：
3.3
通讯作者：
POHOST, GM
中科院分区：
文献类型：
--
作者：
DENHOLLANDER, JA;EVANOCHKO, WT;POHOST, GM
人们正在探索不同的方法，通过活体H-1核磁共振波谱对人体心脏中的心肌脂质进行非侵入性观察。一种方法是使用体积选择和2D梯度相位编码的组合来测量心脏脂质。根据这些数据集，可以重建脂质图像。通过将这些脂肪图像与H-1MR球探图像进行比较，证明这些信号代表了心外膜和心包的脂肪。通过选择较小的条形体积结合一维相位编码或使用单体积技术，可以避免大多数心包和心外膜脂类物质，从而获得显示脂质信号以及三甲胺和(磷酸)肌酸信号的人心脏的H-1核磁共振谱。这些测量结果证明了获取人体心肌H-1核磁共振谱的可行性。
Different approaches are being explored for the noninvasive observation of myocardial lipids in the human heart by in vivo H-1 NMR spectroscopy. One approach is to measure cardiac lipids using a combination of volume selection and 2D gradient phase encoding. From these data sets lipid images can be reconstructed. By comparing these lipid images with H-1 MR scout images, it is demonstrated that these signals represent epicardial and pericardial lipid. By selecting a smaller bar-shaped volume combined with 1D phase encoding or by using single volume techniques, it is possible to avoid most of the pericardial and epicardial lipid to obtain myocardial H-1 NMR spectra of the human heart showing lipid signals, as well as trimethylamine and (phospho)creatine signals. These measurements demonstrate the feasibility of obtaining H-1 NMR spectra of the human myocardium.