Alterations in carbohydrate metabolism in response to short-term dietary carbohydrate restriction
Alterations in carbohydrate metabolism in response to short-term dietary carbohydrate restriction
复制标题
DOI：
10.1152/ajpendo.00069.2005
复制
发表时间：
2005-08-01
影响因子：
5.1
通讯作者：
Horowitz, JF
中科院分区：
文献类型：
--
作者：
Harber, MP;Schenk, S;Horowitz, JF
饮食碳水化合物限制（CR）对葡萄糖稳态提出了挑战。尽管CR饮食很受欢迎，但关于CR的代谢作用知之甚少。本研究的目的是检查饮食CR后全身碳水化合物氧化、葡萄糖利用率、内源性葡萄糖产生和外周葡萄糖摄取的变化，而不受负能量平衡的混杂影响。血浆中葡萄糖出现的吸收后速率（R-a;即，内源性葡萄糖产生）和从血浆中消失（R-d;即，在常规饮食[60%碳水化合物（CHO）、30%脂肪和10%蛋白质; kcals = 1.3 x静息能量消耗（REE）]和CR 2天和7天后，使用同位素稀释法测量葡萄糖摄取8名受试者（平均值+/- SE; 29 +/- 4岁; BMI 24 +/- 1 kg/m（2））在9天的住院访视期间接受了一项研究（5% CHO，60%脂肪和35%蛋白质; kcals = 1.3 x REE）。2天后吸收后血糖浓度降低（P = 0.01），但第二天恢复至饮食前水平，并在整个饮食期间保持在正常血糖水平（饮食前、2天和7天分别为5.1 +/- 0.2、4.3 +/- 0.3和4.8 +/- 0.4 mmol/l）。CR 2天后，葡萄糖R-a和葡萄糖R-d降至低于饮食前水平（9.8 +/- 0.6 mu mol.kg（-1）.min（-1））（7.9 +/- 0.3 mu mol.kg（-1）.min（-1）），7天后仍受到抑制（8.3 +/- 0.4 mu mol.kg（-1）.min（-1）;均P < 0.001）。与葡萄糖R-d的降低相比，碳水化合物氧化的更大抑制导致增加（所有P
Dietary carbohydrate restriction (CR) presents a challenge to glucose homeostasis. Despite the popularity of CR diets, little is known regarding the metabolic effects of CR. The purpose of this study was to examine changes in whole body carbohydrate oxidation, glucose availability, endogenous glucose production, and peripheral glucose uptake after dietary CR, without the confounding influence of a negative energy balance. Postabsorptive rates of glucose appearance in plasma (R-a; i.e., endogenous glucose production) and disappearance from plasma (R-d; i.e., glucose uptake) were measured using isotope dilution methods after a conventional diet [60% carbohydrate (CHO), 30% fat, and 10% protein; kcals = 1.3 x resting energy expenditure (REE)] and after 2 days and 7 days of CR (5% CHO, 60% fat, and 35% protein; kcals = 1.3 x REE) in eight subjects (means +/- SE; 29 +/- 4 yr; BMI 24 +/- 1 kg/m(2)) during a 9-day hospital visit. Postabsorptive plasma glucose concentration was reduced (P = 0.01) after 2 days but returned to prediet levels the next day and remained at euglycemic levels throughout the diet (5.1 +/- 0.2, 4.3 +/- 0.3, and 4.8 +/- 0.4 mmol/l for prediet, 2 days and 7 days, respectively). Glucose R-a and glucose R-d were reduced to below prediet levels (9.8 +/- 0.6 mu mol.kg(-1).min(-1)) after 2 days of CR (7.9 +/- 0.3 mu mol.kg(-1).min(-1)) and remained suppressed after 7 days (8.3 +/- 0.4 mu mol.kg(-1).min(-1); both P < 0.001). A greater suppression in carbohydrate oxidation, compared with the reduction in glucose R-d, led to an increased (all P