Cessation of smoking in patients with intermittent claudication. Effects on the risk of peripheral vascular complications, myocardial infarction and mortality.
Cessation of smoking in patients with intermittent claudication. Effects on the risk of peripheral vascular complications, myocardial infarction and mortality.
复制标题
间歇性跛行患者戒烟。
DOI：
10.1111/j.0954-6820.1987.tb00891.x
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发表时间：
2009
影响因子：
--
通讯作者：
R. Bergström
中科院分区：
文献类型：
--
作者：
T. Jonason;R. Bergström
对343例间歇性跛行患者进行了戒烟效果的研究。初次检查后一年，39人（11%）戒烟，304人（89%）继续吸烟。比较两组的疗效。它们在基线特征方面具有可比性。在任何非吸烟者中均未出现静息痛。在吸烟者中，7年后静息痛的累积比例为16%（p <0.05）。在非吸烟者和吸烟者中，10年后心肌梗死的累积比例分别为11%和53%;心源性死亡的累积率分别为6%和43%; 10年生存率分别为82%和46%。在多变量考克斯回归分析中，吸烟与梗死（p <0.05）和心源性死亡（p <0.05）之间的关联是显著的。生存曲线发生了偏离，在一年的随访后比较，吸烟和死亡率之间的关联是显着的（p <0.05）。这些发现进一步证明了间歇性跛行患者戒烟至关重要。
The effects of cessation of smoking were studied in 343 patients with intermittent claudication. One year after the initial examination 39 (11%) had stopped smoking and 304 (89%) continued to smoke. The outcome in these two groups was compared. They were comparable regarding baseline characteristics. Rest pain did not develop in any of the non-smokers. In smokers the cumulative proportion with rest pain was 16% after seven years (p less than 0.05). The cumulative proportions with myocardial infarctions after 10 years were 11 and 53%; the cumulative rates of cardiac deaths 6 and 43%; and the 10-year survival 82 and 46% among non-smokers and smokers, respectively. In multivariate Cox regression analyses the association between smoking and infarction (p less than 0.05) and cardiac death (p less than 0.05) was significant. The survival curves deviated and when they were compared after one year's follow-up the association between smoking and mortality was significant (p less than 0.05). The findings provide further evidence for the fact that it is of utmost importance that patients with intermittent claudication stop smoking.