A large outbreak of COVID-19 in a UK prison, October 2020 to April 2021.
A large outbreak of COVID-19 in a UK prison, October 2020 to April 2021.
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DOI：
10.1017/s0950268822000991
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发表时间：
2022-05-30
影响因子：
4.2
通讯作者：
Lewis, Heather
中科院分区：
文献类型：
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作者：
Adamson, James P.;Smith, Christopher;Pacchiarini, Nicole;Connor, Thomas Richard;Wallsgrove, Janet;Coles, Ian;Frost, Clare;Edwards, Angharad;Sinha, Jaisi;Moore, Catherine;Perrett, Steph;Craddock, Christie;Sawyer, Clare;Waldram, Alison;Barrasa, Alicia;Thomas, Daniel Rh;Daniels, Philip;Lewis, Heather
监狱很容易爆发疾病以隔离和群聚为重点的控制措施对福祉产生负面影响。我们介绍了2020年10月至2021年4月在英国威尔士一所大型男性监狱爆发的2019年冠状病毒病（COVID-19），并讨论了控制措施。我们收集的情况下，信息，包括人口统计，工作人员居住的邮政编码，居民手机号码，工作区/日期，测试结果，工作人员的采访日期/笔记和居民监狱转移日期。流行病学曲线按监狱位置绘制。控制措施包括隔离（禁止工作或牢房隔离）、群聚（新入院者和工作区群体）、无症状检测（病例发现）、取消公共用餐和行动限制。戴口罩和加强卫生已经到位。全基因组测序（WGS）和访谈确定了病例之间的遗传关系传播的可能性。在453例病例中，53%（n = 242）为工作人员，大多数年龄为25-34岁（11.5%女性，27.15%男性），有症状（64%）。工作人员的粗发病率（29%，95%CI 26-64%）高于居民（12%，95%CI 9-15%）。全基因组测序可以帮助区分监狱中的多次引入和人与人之间的传播。应尽快将其与无症状检测一起引入，以控制监狱疫情。及时的流行病学调查，包括数据可视化，可以进行动态风险评估和相应的控制措施，最大限度地减少居民福利。
Prisons are susceptible to outbreaks. Control measures focusing on isolation and cohorting negatively affect wellbeing. We present an outbreak of coronavirus disease 2019 (COVID-19) in a large male prison in Wales, UK, October 2020 to April 2021, and discuss control measures. We gathered case-information, including demographics, staff-residence postcode, resident cell number, work areas/dates, test results, staff interview dates/notes and resident prison-transfer dates. Epidemiological curves were mapped by prison location. Control measures included isolation (exclusion from work or cell-isolation), cohorting (new admissions and work-area groups), asymptomatic testing (case-finding), removal of communal dining and movement restrictions. Facemask use and enhanced hygiene were already in place. Whole-genome sequencing (WGS) and interviews determined the genetic relationship between cases plausibility of transmission. Of 453 cases, 53% (n = 242) were staff, most aged 25–34 years (11.5% females, 27.15% males) and symptomatic (64%). Crude attack-rate was higher in staff (29%, 95% CI 26–64%) than in residents (12%, 95% CI 9–15%). Whole-genome sequencing can help differentiate multiple introductions from person-to-person transmission in prisons. It should be introduced alongside asymptomatic testing as soon as possible to control prison outbreaks. Timely epidemiological investigation, including data visualisation, allowed dynamic risk assessment and proportionate control measures, minimising the reduction in resident welfare.