Long-term health-related quality of life, growth, and spiritual well-being after hematopoietic stem-cell transplantation
Long-term health-related quality of life, growth, and spiritual well-being after hematopoietic stem-cell transplantation
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DOI：
10.1200/jco.2005.03.189
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发表时间：
2005-01-20
影响因子：
45.3
通讯作者：
Wingard, JR
中科院分区：
文献类型：
--
作者：
Andrykowski, MAA;Bishop, MM;Wingard, JR
目的探讨健康相关的生活质量（HRQOL）和生长，和精神幸福感在造血干细胞移植（HSCT）的成年幸存者为恶性diseases.Methods招募HSCT幸存者（n = 662）通过国际骨髓移植注册/自体血液和骨髓移植注册，并从40个移植中心。HSCT幸存者完成了一个电话采访和一组调查问卷，平均7.0年后HSCT（范围，1.8至22.6年）。研究指标包括HRQOL、生长和精神健康的各种标准化指标。采用同伴提名法招募年龄和性别匹配的健康对照（HQ组，n = 158）。HC组完成了一个平行的电话采访和一组questionnaire.Results多变量方差分析发现，HSCT幸存者组报告较差的状态相对于HC组的所有HRQOL结果集群，包括身体健康，身体功能，社会功能，心理调整，和二元调整。相比之下，HSCT幸存者组报告了更多的心理和人际关系成长。检查的24个结果指数的平均效应量为0.36标准差，通常认为该效应量具有临床意义或重要性。最大的组间差异被发现的一般健康，身体功能和幸福，抑郁，认知功能，和fatigue.Conclusion HSCT的恶性疾病的经验有广泛的，长期的，和深远的影响成人收件人的措施。相对于健康对照组，HSCT幸存者报告较差的身体，心理和社会功能，但相反，更多的心理和人际关系的增长，差异似乎持续多年后HSCT。(C)2005年，美国临床肿瘤学会。
Purpose To examine health-related quality of life (HRQOL) and growth, and spiritual well-being in adult survivors of hematopoietic stem-cell transplantation (HSCT) for a malignant disease.Methods HSCT survivors (n = 662) were recruited through the International Bone Marrow Transplant Registry/Autologous Blood and Marrow Transplant Registry and were drawn from 40 transplantation centers. HSCT survivors completed a telephone interview and a set of questionnaires a mean of 7.0 years post-HSCT (range, 1.8 to 22.6 years). Study measures included a variety of standardized measures of HRQOL and growth and spiritual well-being. An age- and sex-matched healthy comparison (HQ group (n = 158) was recruited using a peer nomination method. The HC group completed a parallel telephone interview and set of questionnaires.Results Multivariate analysis of variance analyses found the HSCT survivor group reported poorer status relative to the HC group for all HRQOL outcome clusters including physical health, physical functioning, social functioning, psychological adjustment, and dyadic adjustment. In contrast, the HSCT survivor group reported more psychological and interpersonal growth. Mean effect size for the 24 outcome indices examined was 0.36 standard deviations, an effect size often considered clinically meaningful or important. The largest group differences were found for measures of general health, physical function and well-being, depression, cognitive function, and fatigue.Conclusion The experience of HSCT for a malignant disease has a wide-ranging, longstanding, and profound impact on adult recipients. Relative to healthy controls, HSCT survivors reported poorer physical, psychological, and social functioning but, conversely, more psychological and interpersonal growth, differences that appeared to persist many years after HSCT. (C) 2005 by American Society of Clinical Oncology.