Strain differences in consumption of saline solutions by mice.
Strain differences in consumption of saline solutions by mice.
复制标题
小鼠消耗盐溶液的菌株差异。
DOI：
10.1016/0031-9384(93)90063-l
复制
发表时间：
1993
影响因子：
2.9
通讯作者：
Fisher,AS
中科院分区：
文献类型：
--
作者：
Beauchamp,GK;Fisher,AS
采用48小时双瓶偏好试验，检查了两种近交系小鼠[C57 BL/6 J（C57）和129/J]雄性动物对盐水（NaCl）溶液和水的摄入量。有一个大的菌株差异，在盐水的摄入量：在中等浓度（0.075-0.150 M）C57小鼠倾向于拒绝盐水相对于水，而129/J小鼠preferably it. Both菌株的小鼠增加其摄入量的盐水lasix诱导的钠消耗和偏好表现出的129/J小鼠为0.15 M NaCl消除后，氯化锂中毒。C57对中等浓度盐水的排斥至少部分是由于先前暴露于等渗或高渗盐水溶液：先前未暴露于盐水的C57小鼠比先前暴露于0.30 M NaCl的C57小鼠表现出更大的盐水摄入量。129/J小鼠的盐水偏好不受先前暴露于0.30 M NaCl的影响。因此，小鼠盐偏好的品系差异部分是由于C57小鼠而不是129/J小鼠摄入盐水后的后果。
Intake of saline (NaCl) solutions and water by males of two inbred strains of mice [C57BL/6J (C57) and 129/J] were examined using 48-h, two-bottle preference tests. There was a large strain difference in saline intake: at moderate concentrations (0.075–0.150 M) C57 mice tended to reject saline relative to water, whereas 129/J mice preferred it. Both strains of mice increased their intake of saline following lasix-induced sodium depletion and the preference exhibited by 129/J mice for 0.15 M NaCl was eliminated following LiCl toxicosis. The rejection of moderate concentrations of saline by C57 was shown to be due, in part at least, to prior exposure to iso- or hypertonic saline solutions: C57 mice that had no prior exposure to saline exhibited a greater intake of saline than C57 mice previously exposed to 0.30 M NaCl. Saline preferences of the 129/J mice were not affected by prior exposure to 0.30 M NaCl. Thus, the strain difference in mouse salt preference is due in part to postingestional consequences of saline consumption in C57 but not 129/J mice.