Role of endothelin ETB receptor activation in angiotensin II-induced hypertension:: effects of salt intake
Role of endothelin ETB receptor activation in angiotensin II-induced hypertension:: effects of salt intake
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DOI：
10.1152/ajpheart.2001.281.5.h2218
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发表时间：
2001-11-01
影响因子：
4.8
通讯作者：
Fink, GD
中科院分区：
文献类型：
--
作者：
Ballew, JR;Fink, GD
我们最近发现内皮素（ET） A受体参与了ANG ii诱导的高血压的盐敏感性。本研究的目的是表征内皮素ETB受体激活在同一模型中的作用。正常（2 meq/天）或高（6 meq/天）盐摄入量固定的雄性大鼠接受ANG II或盐的连续静脉输注，仅持续15天。在输注期的中间5天，大鼠分别给予选择性内皮素受体拮抗剂A-192621和非选择性内皮素受体拮抗剂A-182086，剂量均为24 mg.kg（-1）。(1)动脉内的)。在高盐摄入的大鼠中，输注ANG II引起了更大的动脉压升高。给药A-192621使所有大鼠的动脉压进一步升高。A-192621对慢性高血压的影响不受盐摄入量或ANG II的显著影响。给药A-182086长期降低动脉压仅在正常盐摄入量的大鼠接受ANG II。因此，angii诱导的高血压的盐敏感性不是由ETB受体功能的改变引起的。
We showed recently that endothelin (ET) A receptors are involved in the salt sensitivity of ANG II-induced hypertension. The objective of this current study was to characterize the role of endothelin ETB receptor activation in the same model. Male rats on fixed normal (2 meq/day) or high (6 meq/day) salt intake received a continuous intravenous infusion of ANG II or salt only for 15 days. During the middle 5 days of the infusion period, rats were given either the selective ETB receptor antagonist A-192621 or the nonselective endothelin receptor antagonist A-182086 (both at 24 mg.kg(-1).day(-1) intra-arterially). Infusion of ANG II caused a greater rise in arterial pressure in rats on high-salt intake. The administration of A-192621 increased arterial pressure further in all rats. The chronic hypertensive effect of A-192621 was not significantly affected by salt intake or ANG II. The administration of A-182086 lowered arterial pressure chronically only in rats on normal salt intake receiving ANG II. Thus the salt sensitivity of ANG II-induced hypertension is not caused by changes in ETB receptor function.