RANTES: a versatile and controversial chemokine
RANTES: a versatile and controversial chemokine
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DOI：
10.1016/s1471-4906(00)01812-3
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发表时间：
2001-02-01
影响因子：
16.8
通讯作者：
Rowland-Jones, SL
中科院分区：
文献类型：
--
作者：
Appay, V;Rowland-Jones, SL
趋化因子RANTES的活性不仅限于趋化性。它是一种强大的白细胞激活剂，这是一种与一系列炎症性疾病潜在相关的特征。RANTES引起了人们的注意，因为它可以有效地抑制，并在某些情况下，增强艾滋病毒的复制。这些特征主要取决于其自聚集和结合糖胺聚糖的能力。
The activity of the chemokine RANTES is not restricted merely to chemotaxis. It is a powerful leukocyte activator, a feature potentially relevant in a range of inflammatory disorders. RANTES has attracted attention because it can potently suppress and, in some circumstances, enhance HIV replication. These characteristics are critically dependent on its ability to self-aggregate and bind to glycosaminoglycans.