Effect of chronic uremia on the cardiovascular alpha 1 receptor.
Effect of chronic uremia on the cardiovascular alpha 1 receptor.
复制标题
慢性尿毒症对心血管α1受体的影响。
DOI：
10.1016/0024-3205(86)90452-2
复制
发表时间：
1986
期刊：
影响因子：
6.1
通讯作者：
Goodman,AI
中科院分区：
文献类型：
--
作者：
Meggs,LG;Ben-Ari,J;Gammon,D;Choudhury,M;Goodman,AI
Adrenergic dysfunction in uremia has been well described. Several lines of evidence suggest disorders of blood pressure regulation and myocardial response may occur secondary to adrenergic dysfunction; 1) attenuated pressor response to norepinephrine (NE) in uremia; 2) attenuated chronotropic responses during dialysis induced hypotension. Since the adrenergic receptors are the effector component of the adrenergic nervous system, we have employed the partially nephrectomized uremic rat, to examine the effect of chronic uremia (4–6 weeks) on the binding properties of alpha1receptors in rat mesenteric artery and myocardial tissue. The results indicate that moderate levels of uremia alter the binding properties of both the alpha1vascular and myocardial receptor.
