Depression following traumatic brain injury: a comprehensive overview
Depression following traumatic brain injury: a comprehensive overview
复制标题
DOI：
10.1515/revneuro-2020-0037
复制
发表时间：
2021-04-01
影响因子：
4.1
通讯作者：
Lawand, Nada
中科院分区：
文献类型：
--
作者：
Fakhoury, Marc;Shakkour, Zaynab;Lawand, Nada
创伤性脑损伤（TBI）是影响神经心理健康的主要健康问题; TBI伴随着严重的长期不良并发症，可能影响受影响个体生活的许多方面。大量的研究表明，情绪障碍，特别是抑郁症，是TBI患者最常见的并发症。创伤后抑郁症（P-TD）存在于大约30%的TBI患者中，大多数人在头部受伤后的第一年内经历抑郁症状。迄今为止，P-TD的机制远未完全了解，并且仍然缺乏完全阻止这种情况的有效治疗方法。本综述的目的是概述P-TD的患病率和危险因素的知识现状，讨论伴随的大脑在解剖，分子和功能水平的变化，并讨论目前用于治疗P-TD的方法。
Traumatic brain injury (TBI) represents a major health concern affecting the neuropsychological health; TBI is accompanied by drastic long-term adverse complications that can influence many aspects of the life of affected individuals. A substantial number of studies have shown that mood disorders, particularly depression, are the most frequent complications encountered in individualswith TBI. Post-traumatic depression (P-TD) is present in approximately 30% of individuals with TBI, with the majority of individuals experiencing symptoms of depression during the first year following head injury. To date, the mechanisms of P-TD are far from being fully understood, and effective treatments that completely halt this condition are still lacking. The aim of this review is to outline the current state of knowledge on the prevalence and risk factors of P-TD, to discuss the accompanying brain changes at the anatomical, molecular and functional levels, and to discuss current approaches used for the treatment of P-TD.