DIFFERENTIAL SENSITIVITY OF TETRODOTOXIN-SENSITIVE AND TETRODOTOXIN-RESISTANT SODIUM-CHANNELS TO THE INSECTICIDE ALLETHRIN IN RAT DORSAL-ROOT GANGLION NEURONS
DIFFERENTIAL SENSITIVITY OF TETRODOTOXIN-SENSITIVE AND TETRODOTOXIN-RESISTANT SODIUM-CHANNELS TO THE INSECTICIDE ALLETHRIN IN RAT DORSAL-ROOT GANGLION NEURONS
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DOI：
10.1016/0006-8993(93)90326-i
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发表时间：
1993-11-12
期刊：
影响因子：
2.9
通讯作者：
NARAHASHI, T
中科院分区：
文献类型：
--
作者：
GINSBURG, KS;NARAHASHI, T
已知拟除虫菊酯杀虫剂会改变神经元钠通道，导致全细胞电流延长。大鼠背根神经节神经元表达的钠通道有两种类型，一种对河鲀毒素高度敏感，另一种对河鲀毒素高度抵抗。拟除虫菊酯丙烯菊酯对河豚毒素抗性钠通道产生深远影响，而对河豚毒素敏感钠通道影响最小。来自抗河豚毒素钠通道的电流在逐步去极化过程中大大延长；再极化时的尾电流也增强并延长。在河豚毒素敏感的钠通道电流中，丙烯菊酯引起的这些变化要小得多或可以忽略不计。丙烯菊酯不会显着改变河豚毒素抗性峰值钠电流的激活和失活电压。丙烯菊酯对两种类型钠通道的不同作用不仅对于识别目标分子结构很重要，而且对于解释哺乳动物中毒症状也很重要。
The pyrethroid insecticides are known to modify neuronal sodium channels to cause a prolongation of whole cell current. The sodium channels expressed in the dorsal root ganglion neurons of the rat are of two types, one highly sensitive to tetrodotoxin and the other highly resistant to tetrodotoxin. The pyrethroid allethrin exerted profound effects on tetrodotoxin-resistant sodium channels while causing minimal effects on tetrodotoxin-sensitive sodium channels. Currents derived from tetrodotoxin-resistant sodium channels were greatly prolonged during a step depolarization; the tail currents upon repolarization were also augmented and prolonged. In the tetrodotoxin-sensitive sodium channel currents, these changes caused by allethrin were much smaller or negligible. The activation and inactivation voltages of tetrodotoxin-resistant peak sodium currents were not significantly altered by allethrin. The differential action of allethrin on the two types of sodium channels would be important not only in identifying the target molecular structure but also in interpreting the symptoms of poisoning in mammals.