Effect of acute sleep deprivation and recovery on Insulin-like Growth Factor-I responses and inflammatory gene expression in healthy men
Effect of acute sleep deprivation and recovery on Insulin-like Growth Factor-I responses and inflammatory gene expression in healthy men
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DOI：
10.1684/ecn.2014.0356
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发表时间：
2014-09-01
影响因子：
2.8
通讯作者：
Nindl, Bradley C.
中科院分区：
文献类型：
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作者：
Chennaoui, Mounir;Drogou, Catherine;Nindl, Bradley C.
研究发现，人类急性睡眠剥夺会通过可能的 Toll 样受体 4 (TLR-4) 增加外周炎症标志物和信号传导通路。此外，睡眠时间短与循环总胰岛素样生长因子-I (IGF-I) 浓度低有关。我们的目的是确定恢复后的完全睡眠剥夺 (TSD) 方案是否会改变促炎细胞因子 TNF-α 和 IL-6 的全血基因表达以及 TLR-4 表达，并检查与 IGF-I 系统循环浓度的关系。十二名健康男性参加了为期五天的 TSD（两个对照晚上，随后一晚睡眠剥夺和一晚恢复）。在 0800 点、睡眠剥夺之前和之后（D2 和 D4）以及恢复之后（D5）采集血液样本。结果表明，25小时的睡眠剥夺（D4）导致TNF-α及其可溶性受体R1的mRNA水平显着增加（P
Acute sleep deprivation in humans has been found to increase inflammatory markers and signaling pathways in the periphery through a possible Toll-like receptor 4 (TLR-4). In addition, short duration sleep has been associated with low circulating total Insulin-like Growth Factor-I (IGF-I) concentrations. We aimed to determine whether a total sleep deprivation (TSD) protocol with recovery altered whole-blood gene expression of the proinflammatory cytokines TNF-alpha and IL-6, as well as TLR-4 expression, and to examine the relationship with circulating concentrations of the IGF-I system. Twelve healthy men participated in a five-day TSD (two control nights followed by one night of sleep deprivation and one night of recovery). Blood was sampled at 0800, before and after sleep deprivation (D2 and D4), and after recovery (D5). It is shown that 25h of sleep deprivation (D4) induced significant increases in mRNA levels of TNF-alpha and its soluble receptor R1 (P