Response to Rv2628 latency antigen associates with cured tuberculosis and remote infection
Response to Rv2628 latency antigen associates with cured tuberculosis and remote infection
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DOI：
10.1183/09031936.00140009
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发表时间：
2010-07-01
影响因子：
24.3
通讯作者：
Girardi, E.
中科院分区：
文献类型：
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作者：
Goletti, D.;Butera, O.;Girardi, E.
基于差异区1抗原的干扰素-γ释放测定改善了潜伏性结核感染（LTBI）的诊断。然而，这些测试不能区分最近获得的感染（进展为活动性结核的风险较高）和远程LTBI。本研究的目的是评估T细胞干扰素-γ对结核分枝杆菌DosR-调节子编码抗原（潜伏抗原）的反应，并与QuantiFERON TB-Gold In-Tube（QFT-GIT）进行比较。结果表明，远处LTBI患者对M.肺结核潜伏抗原Rv 2628的表达显著高于近期感染者、活动性肺结核患者和对照组（p
Interferon-gamma release assays based on region of difference 1 antigens have improved diagnosis of latent tuberculosis infection (LTBI). However, these tests cannot discriminate between recently acquired infection (higher risk of progression to active tuberculosis) and remote LTBI. The objective of the present study was to evaluate the T-cell interferon-gamma responses to Mycobacterium tuberculosis DosR-regulon-encoded antigens (latency antigens) compared with QuantiFERON TB-Gold In-Tube (QFT-GIT) in subjects at different stages of tuberculosis.A total of 16 individuals with remote LTBI and 23 with recent infection were studied; 15 controls unexposed to M. tuberculosis and 50 patients with active tuberculosis and 45 with cured tuberculosis were also analysed.The results indicated that subjects with remote LTBI showed significantly higher whole-blood interferon-gamma responses to M. tuberculosis latency antigen Rv2628 than did individuals with recent infection, active tuberculosis and controls (p