Fasting increases and satiation decreases olfactory detection for a neutral odor in rats
Fasting increases and satiation decreases olfactory detection for a neutral odor in rats
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DOI：
10.1016/j.bbr.2007.02.012
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发表时间：
2007-05-16
影响因子：
2.7
通讯作者：
Julliard, A. K.
中科院分区：
文献类型：
--
作者：
Aime, P.;Duchamp-Viret, P.;Julliard, A. K.
嗅觉在摄食行为中起着重要的作用，但嗅觉灵敏度随摄食状态的变化从未在动物中得到精确的证明。本研究评估了严格控制食物摄入方案下禁食或饱足大鼠的嗅觉检测性能。我们使用条件性气味厌恶（COA）方案来进行这一实验，该方案在大鼠中诱导对10（-5）（100 ml水中1 μ l）的ISO气味化饮料的几乎完全厌恶。然后给大鼠（禁食或吃饱）不同浓度的ISO加臭水，以比较它们检测并避免ISO饮料的能力。在这两种状态下，大鼠在10（-10）、10（-9）和10（-8）时消耗的ISO体积显著大于10（-5）时，表明在这三种浓度下检测较低，尽管禁食大鼠消耗的ISO饮料显著少于饱足大鼠，这些实验提供了原始数据，证明了预期的事实，即在禁食的情况下嗅觉灵敏度增加。动物由于这些结果是使用中性气味获得的，因此我们认为禁食期间嗅觉灵敏度增加，使动物能够更容易地检测食物和环境气味，例如捕食者的气味。这将有一个明显的生态行为学的作用，增加嗅觉输入的相关性时，寻求食物。(c)2007 Elsevier B. V.保留所有权利。
Olfaction plays a fundamental role in feeding behavior, but changes in olfactory acuity according to feeding states have never been precisely demonstrated in animals. The present study assesses the olfactory detection performance of fasted or satiated rats placed under a strictly controlled food-intake regimen. We did this using a conditioned odor aversion (COA) protocol which induced in rats an almost total aversion to an ISO-odorized drink at 10(-5) (1 mu l in 100 ml of water). The rats (either fasted or satiated) were then presented with different concentrations of ISO-odorized water to compare their ability to detect and so avoid the ISO drink. In both states, the rats consumed significantly larger volumes of ISO at 10(-10), 10(-9) and 10(-8) than at 10(-5), suggesting lower detection at these three concentrations, although the fasted rats consumed significantly less ISO drink than did the satiated ones, showing better ISO detection at these concentrations.These experiments provide original data demonstrating the expected fact that olfactory sensitivity increases in fasted animals. Since these results were obtained using a neutral odor, we suggest that olfactory acuity increases during fasting, enabling animals to more easily detect both food and environmental odors such as those of predators. This would have an obvious eco-ethological role by increasing the relevance of olfactory inputs when seeking food. (c) 2007 Elsevier B.V. All rights reserved.