Reinforcement of a new calcium phosphate cement with RGD-chitosan-fiber
Reinforcement of a new calcium phosphate cement with RGD-chitosan-fiber
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RGD-壳聚糖纤维增强新型磷酸钙水泥
DOI：
10.1002/jbm.a.34669
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发表时间：
2014-01-01
影响因子：
4.9
通讯作者：
Huang, Ye
中科院分区：
文献类型：
--
作者：
Wu, Tian-Yi;Zhou, Zu-Bin;Huang, Ye
磷酸钙骨水泥(CPC)已广泛应用于骨科和牙科。CPC的一个关键缺陷是强度低，对严重骨折的敏感性高。外科医生只能用它来重建非应力承重骨，这增加了对更坚韧的新一代CPC的需求。纤维被用作CPC的增强材料，以提高纯CPC支架的强度。RGD多肽(Arg-Gly-Asp)被用来通过物理吸附来改善支架的生物相容性。本研究的目的是研制一种新型的含RGD多肽的壳聚糖纤维增强CPC支架(RGD-纤维-CPC)。我们的数据显示，RGD-纤维-CPC支架的弯曲强度增加，并在动物模型中刺激新骨形成。RGD-纤维-CPC是骨科手术中一种新型的骨移植替代物。(C)2013 Wiley期刊，Inc.生物材料资源A部分：102A：68-75,2014。
Calcium phosphate cement (CPC) has been widely used in orthopedic and dental applications. A critical limitation of CPC is low strength and high susceptibility to severe fracture. Surgeons can use it only to reconstruct non-stress bearing bone, raising the need for a tougher new generation of CPC. Fibers have been used as a reinforcement of CPC to improve the strength of a pure CPC scaffold. The RGD peptides (Arg-Gly-Asp) have been used to improve the biocompatibility of the scaffold, via physical adsorption. The purpose of this study was to develop a novel CPC scaffold reinforced by RGD peptide-bearing chitosan fibers (RGD-fiber-CPC). Our data showed that the RGD-fiber-CPC scaffold had an increased flexural strength, and stimulated new bone formation in an animal model. The RGD-fiber-CPC is a novel bone graft substitute in orthopedic surgery. (c) 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 68-75, 2014.