Associations of ambient particulate matter with homocysteine metabolism markers and effect modification by B vitamins and MTHFR C677T gene polymorphism.
Associations of ambient particulate matter with homocysteine metabolism markers and effect modification by B vitamins and MTHFR C677T gene polymorphism.
复制标题
DOI：
10.1016/j.envpol.2020.116211
复制
发表时间：
2020-12
影响因子：
8.9
通讯作者：
Bo-yi Yang;Ke Cao;Ya-Na Luo;Zhi-Zhou He;Peng-Yue Guo;Huimin Ma;Mo Yang;Yang Zhou;L. Hu;Gongbo Chen;X. Zeng;Hongyao Yu;Yunjiang Yu;G. Dong
中科院分区：
文献类型：
--
作者：
Bo-yi Yang;Ke Cao;Ya-Na Luo;Zhi-Zhou He;Peng-Yue Guo;Huimin Ma;Mo Yang;Yang Zhou;L. Hu;Gongbo Chen;X. Zeng;Hongyao Yu;Yunjiang Yu;G. Dong
关于环境空气污染对同型半胱氨酸(HCY)代谢影响的证据很少。我们的目的是探索环境颗粒物(PM)暴露与HCY代谢标志物之间的关系，并评估叶酸、维生素B12和亚甲基四氢叶酸还原酶(MTHFR)C677T基因多态性对效果的影响。2017年12月1日至2018年1月5日，我们对广州市88名青年大学生中国进行了小组研究，并接受了5轮健康检查。实时监测空气动力学直径为PM2.5、PM1.0和PM0.1的PM的浓度，并重复测定血清≤代谢标志物：≤、S-同型半胱氨酸和S-腺苷蛋氨酸。我们应用线性混合效应模型结合分布滞后模型来评估PM与HCY代谢标记物的相关性。我们还探讨了叶酸、维生素B12和MTHFR C677T多态对这些关联的影响。我们观察到，PM2.5和PM1.0浓度越高，血清HCY、SAH、SAM和SAM/SAH比值越高(例如，在滞后0天和滞后5天PM2.5增加10μg/m~3分别与HCY、SAH、SAM和SAM/SAH比值分别增加1.3-19.4%、1.3-28.2%、6.2-64.4%和4.8-28.2%相关)。此外，我们观察到，在维生素B水平较低的参与者中，PM2.5与HCY代谢标记物的相关性更强。这项研究表明，短期暴露于PM2.5和PM1.0与HCY代谢标记物有害相关，尤其是在维生素B水平较低的人。
Evidence concerning effects of ambient air pollution on homocysteine (HCY) metabolism is scarce. We aimed to explore the associations between ambient particulate matter (PM) exposure and the HCY metabolism markers and to evaluate effect modifications by folate, vitamin B12, and methylenetetrahyfrofolate reductase (MTHFR) C677T gene polymorphism. Between December 1, 2017 and January 5, 2018, we conducted a panel study in 88 young college students in Guangzhou, China, and received 5 rounds of health examinations. Real-time concentrations of PMs with aerodynamic diameter ≤2.5 (PM2.5), ≤1.0 (PM1.0), and ≤0.1 (PM0.1) were monitored, and the serum HCY metabolism markers (i.e., HCY, S-Adenosylhomocysteine [SAH], and S-Adenosylmethionine [SAM]) were repeatedly measured. We applied linear mixed effect models combined with a distributed lag model to evaluate the associations of PMs with the HCY metabolism markers. We also explored effect modifications of folate, vitamin B12, and theMTHFR C677T polymorphism on the associations. We observed that higher concentrations of PM2.5and PM1.0were associated with higher serum levels of HCY, SAH, SAM, and SAM/SAH ratio (e.g., a 10 μg/m3increase in PM2.5during lag 0 day and lag 5 day was significantly associated with 1.3–19.4%, 1.3–28.2%, 6.2–64.4%, and 4.8–28.2% increase in HCY, SAH, SAM, and SAM/SAH ratio, respectively). In addition, we observed that the associations of PM2.5with the HCY metabolism markers were stronger in participants with lower B vitamins levels. This study demonstrated that short-term exposure to PM2.5and PM1.0was deleteriously associated with the HCY metabolism markers, especially in people with lower B vitamins levels.