The mode of action of vitamin D. Studies on hypervitaminosis D. The influence of the calcium-phosphate intake.
The mode of action of vitamin D. Studies on hypervitaminosis D. The influence of the calcium-phosphate intake.
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DOI：
10.1042/bj0250367
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发表时间：
1931-01-01
影响因子：
4.1
通讯作者：
Innes, JRM
中科院分区：
文献类型：
--
作者：
Harris, LJ;Innes, JRM
饮食中钙含量的增加会加剧维生素过多症的严重程度，并在一定水平的维生素 D 过量的情况下导致钙质沉积。在钙和磷酸盐含量低且维生素 D 含量高的饮食中，骨物质会发生再吸收。正常饮食中大剂量的维生素 D 会刺激成骨，与维生素 D 缺乏症的结果相反，血钙或磷酸盐或两者通常都很高。维生素 D 增加肠道对钙和磷酸盐的吸收。
An increase in the Ca content of a diet intensifies the severity of hypervitaminosis and gives rise to calcareous deposits for a given level of vitamin D excess. On diets low in Ca and phosphate and with high excess of vitamin D, resorp-tion of bone substance occurs. Large doses of vitamin D stimulate osteogenesis on normal diets, and in contrast to the findings in vitamin D deficiency, blood Ca, or phosphate, or both, are usually high. Vitamin D increases the absorption of Ca and phosphate from the gut.