THE GLUCOSE PARADOX - IS GLUCOSE A SUBSTRATE FOR LIVER-METABOLISM
THE GLUCOSE PARADOX - IS GLUCOSE A SUBSTRATE FOR LIVER-METABOLISM
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DOI：
10.1172/jci111610
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发表时间：
1984-01-01
影响因子：
15.9
通讯作者：
MCGARRY, JD
中科院分区：
文献类型：
--
作者：
KATZ, J;MCGARRY, JD
总之，毫无疑问，体内葡萄糖负荷会抑制甚至阻断葡萄糖输出。此外，当血糖浓度在实验上升高到12-15 mM的范围时，肝脏将以大量的葡萄糖摄取作出反应。应该记住，游离葡萄糖是一种罕见的饮食成分，即使是高淀粉饮食，门静脉葡萄糖浓度也很少达到12 mM。在大鼠和犬中，当动物适应高葡萄糖饮食时，葡萄糖摄取的阈值降低到生理范围。现有证据清楚地表明，在西式饮食的人类中，肝脏对葡萄糖的摄取相当低，并且所施用的葡萄糖主要在外周代谢。
In summary, there is no question that in vivo a glucose load will depress and perhaps even block glucose output. Also, when blood glucose concentrations are experimentally raised to a range of 12-15 mM, the liver will respond with substantial glucose uptake. It should be remembered that free glucose is a rare dietary component, and even with high starch diets, portal glucose concentrations will seldom reach 12 mM. In rats and dogs, the threshold for glucose uptake is lowered to the physiological range when the animals are conditioned to a high glucose diet. The available evidence shows clearly that in humans on a Western-type diet, the uptake of glucose by the liver is quite low, and the administered glucose is metabolized predominantly in the periphery.