Category-specific modulation of inferior temporal activity during working memory encoding and maintenance
Category-specific modulation of inferior temporal activity during working memory encoding and maintenance
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DOI：
10.1016/j.cogbrainres.2003.11.017
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发表时间：
2004-06-01
期刊：
影响因子：
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通讯作者：
D'Esposito, M
中科院分区：
文献类型：
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作者：
Ranganath, C;DeGutis, J;D'Esposito, M
神经生理学的发现支持这样的观点，即视觉工作记忆(WM)依赖于对颞叶下部皮质中对象选择性神经元群体活动的调节。在这里，我们使用事件相关的功能磁共振成像，研究了类似的机制是否支持人类视觉工作记忆的编码和维护过程。我们确定了在对面孔(梭形面孔区域[FFA])或场景(海马旁位置区域[PPA])的感知过程中，颞叶下部皮质中表现出类别特异性反应的区域，并调查了这些区域的活动是否会受到主动编码和维持面孔和场景的需求的调节。结果表明，当FFA和PPA偏爱的刺激与识别任务相关时，它们独立于知觉刺激，表现出更大的编码和维持相关活动。相比之下，背外侧前额叶皮质(PFC)中与维持相关的活动受到记忆负荷的调节，而与任务相关的信息类型无关。这些结果与视觉工作记忆的编码和维持过程是通过前额叶皮质调节下层时间活动来实现的观点是一致的。(C)2004爱思唯尔B.V.保留所有权利。
Findings from neurophysiology have supported the view that visual working memory (WM) relies on modulation of activity in object-selective populations of neurons in inferior temporal cortex. Here, using event-related functional magnetic resonance imaging, we investigated whether similar mechanisms support human visual working memory encoding and maintenance processes. We identified regions in inferior temporal cortex that exhibited category-specific responses during perception of faces (fusiform face area [FFA]) or scenes (parahippocampal place area [PPA]) and investigated whether activity in these regions would be modulated by demands to actively encode and maintain faces and scenes. Results showed that independent of perceptual stimulation, the FFA and PPA exhibited greater encoding- and maintenance-related activity when their favored stimulus was relevant to the recognition task. In contrast, maintenance-related activity in the dorsolateral prefrontal cortex (PFC) was modulated by memory load, regardless of the type of information that was task relevant. These results are consistent with the view that visual working memory encoding and maintenance processes are implemented through modulation of inferior temporal activity by prefrontal cortex. (C) 2004 Elsevier B.V. All rights reserved.