The changing epidemiology of hepatitis C virus infection in the United States: National health and nutrition examination survey 2001 through 2010
The changing epidemiology of hepatitis C virus infection in the United States: National health and nutrition examination survey 2001 through 2010
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DOI：
10.1016/j.jhep.2013.11.014
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发表时间：
2014-04-01
影响因子：
25.7
通讯作者：
Charlton, Michael
中科院分区：
文献类型：
--
作者：
Ditah, Ivo;Ditah, Fausta;Charlton, Michael
背景与目的：鉴于丙型肝炎治疗前景的急剧变化，了解美国普通人群中当前丙型肝炎感染负担至关重要。方法：国家健康和营养检查调查收集了美国平民人群中HCV感染的全国代表性数据。这项研究结合了2001年至2010年的数据。在38,025名参与者中完成了HCV检测。结果：美国的抗- hcv患病率从2001-2002年的1.9% （95% CI 1.5%-2.5%）下降到2005-2006年的1.3% (95% CI 0.9%-1.8%)，并保持稳定直到2010年。约67%的感染者HCV RNA呈阳性，表明230万人患有慢性HCV感染，其中68%为基因1型。70%的感染者出生于1945年至1965年之间，患病率为3.5%（95%可信区间2.2%-4.8%）。自2006年以来，稳定的比率主要与流行病例和移民到美国的外国出生的人有关。其他重要的风险因素包括教育程度低和经济地位低。种族、艾滋病毒状况、性伴侣数量和输血不再与丙型肝炎病毒感染相关。结论：截至2010年，美国约有230万人慢性丙型肝炎感染。大多数感染者是普遍的，而不是偶然的病例。丙型肝炎病毒的流行率呈下降趋势，但自2006年以来已趋于稳定。未来的研究应该探索自2006年以来丙型肝炎患病率没有下降的原因。(C) 2013欧洲肝脏研究协会。Elsevier b.v.版权所有。
Background & Aims: In light of the dramatically changing hepatitis C therapeutic landscape, knowledge of the current burden of HCV infection in the general population of the United States is critical.Methods: The National Health and Nutrition Examination survey collects nationally representative data on HCV infection in the civilian population of the United States. Data from 2001 to 2010 were combined for this study. HCV testing was completed in 38,025 participants.Results: The prevalence of anti-HCV in the United Sates decreased from 1.9% (95% CI 1.5%-2.5%) in 2001-2002 to 1.3% (95% CI 0.9%-1.8%) in 2005-2006, and remained stable up to 2010. About 67% of all infected persons were positive for HCV RNA, indicating 2.3 million people with chronic HCV infection, of whom 68% have genotype 1. Seventy percent of infected persons were born between 1945 and 1965, with prevalence of 3.5% (95% CI 2.2%-4.8%). The stable rate since 2006 is mostly related to prevalent cases and foreign born persons migrating into US. Other important risk factors include less education and low economic status. Race, HIV status, number of sexual partners, and blood transfusions are no longer associated with HCV infection.Conclusions: As of 2010, approximately 2.3 million persons were chronically infected with Hepatitis C in the US. Most of those infected are prevalent, rather than incident cases. The prevalence of HCV was on the decline, but has stabilized since 2006. Future studies should explore reasons for no decline in HCV prevalence since 2006. (C) 2013 European Association for the Study of the Liver. Published by Elsevier B. V. All rights reserved.