Role of bacteria in the etiopathogenesis of inflammatory bowel disease
Role of bacteria in the etiopathogenesis of inflammatory bowel disease
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DOI：
10.3748/wjg.v13.i42.5571
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发表时间：
2007-11-14
影响因子：
4.3
通讯作者：
Darfeuille-Michaud, Arlette
中科院分区：
文献类型：
--
作者：
Barnich, Nicolas;Darfeuille-Michaud, Arlette
在克罗恩病（CD）和溃疡性结肠炎（UC）这两种主要炎症性肠病中都观察到粘膜相关大肠杆菌数量增加。怀疑致病性侵入细菌的存在与回肠 CD 患者的遗传宿主易感性之间存在潜在的病理生理学联系。在CD患者中，随着作为I型菌毛细菌粘附素识别的受体的CEACAM6分子的回肠表达增加，并且随着NOD2编码基因突变的鉴定，致病性入侵细菌的存在可能是异常回肠细菌定植和对入侵细菌的先天免疫反应之间的联系。在易感宿主中，粘附侵袭性大肠杆菌 (AIEC) 诱发疾病的连续病因学步骤是：(1) 通过与 CEACAM6 受体结合而形成异常定植，该受体在 CD 患者的回肠粘膜中过度表达； （2）粘附和侵入肠上皮细胞的能力，使细菌能够穿过粘膜屏障； (3)固有层中受感染巨噬细胞的存活和复制； (4)诱导肿瘤坏死因子-α分泌和肉芽肿形成。 (c) 2007 年 WJG。版权所有。
Increased numbers of mucosa-associated Escherichia coli are observed in both of the major inflammatory bowel diseases, Crohn's disease (CD) and ulcerative colitis (UC). A potential pathophysiological link between the presence of pathogenic invasive bacteria and genetic host susceptibility of patients with ileal CD is suspected. In CD patients, with increased ileal expression of the CEACAM6 molecule acting as a receptor recognized by type I pilus bacterial adhesin, and with the identification of mutations in the NOD2-encoding gene, the presence of pathogenic invasive bacteria could be the link between abnormal ileal bacterial colonization and innate immune responses to invasive bacteria. In a susceptible host, the sequential etiological steps of the disease induced by adherent-invasive E. coli (AIEC) are: (1) abnormal colonization via binding to the CEACAM6 receptor, which is overexpressed in the ileal mucosa of CD patients; (2) ability to adhere to and to invade intestinal epithelial cells, which allows bacteria to cross the mucosal barrier; (3) survival and replication within infected macrophages in the lamina propria; and (4) induction of tumor necrosis factor-alpha secretion and granuloma formation. (c) 2007 WJG. All rights reserved.