Neuropsychological aspects of pediatric sickle cell disease
Neuropsychological aspects of pediatric sickle cell disease
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DOI：
10.1023/a:1012901124088
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发表时间：
2001-12-01
影响因子：
5.8
通讯作者：
Hynd, GW
中科院分区：
文献类型：
--
作者：
Kral, MC;Brown, RT;Hynd, GW
镰状细胞病（SCD）是一类以异常镰状红细胞为特征的遗传性疾病，是一种导致进行性脑血管疾病的慢性疾病。SCD儿童临床上明显的脑血管意外的神经认知后遗症的特征是广泛的损害，包括一般智力功能、语言和言语能力、视觉运动和视觉空间处理、记忆、学业成绩和微妙韵律信息处理的下降。相比之下，注意力和集中力、执行功能、视觉运动速度和协调等领域的细微神经认知缺陷似乎与体格检查不一定检测到的无症状性梗死相关。调查的疾病过程和相关的神经认知后遗症提出了一种疾病特异性模型的神经心理障碍。建议在儿科神经心理学领域的临床和研究工作。
Sickle cell disease (SCD), a class of genetic disorders characterized by abnormal, sickled red blood cells, is a chronic illness that results in progressive cerebrovascular disease. Neurocognitive sequelae of clinically apparent cerebrovascular accidents in children with SCD are characterized by pervasive impairments, including decrements in general intellectual functioning, language and verbal abilities, visual-motor and visual-spatial processing, memory, academic achievement, and processing of subtle prosodic information. In contrast, subtle neurocognitive deficits in the areas of attention and concentration, executive function, and visual-motor speed and coordination appear to be associated with silent infarcts that are not necessarily detected on physical examination. Investigation of the disease course and associated neurocognitive sequelae suggest a disease-specific model of neuropsychological impairment. Recommendations are made for clinical and research efforts in the field of pediatric neuropsychology.