Bacterial virulence strategies that utilize Rho GTPases.
Bacterial virulence strategies that utilize Rho GTPases.
复制标题
利用 Rho GTPases 的细菌毒力策略。
DOI：
10.1007/3-540-27511-8_1
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发表时间：
2005
影响因子：
--
通讯作者：
B. Finlay
中科院分区：
文献类型：
--
作者：
B. Finlay
改变宿主中心细胞功能的能力是许多细菌病原体使用这种策略作为其毒力机制的一部分的主要优势。小gtp酶，包括Rho gtp酶，由于其在调节细胞功能（如细胞骨架控制）中的核心作用，成为病原体特别有吸引力的靶标。这些GTPase的修饰可以包括对GTPase的直接化学修饰或与一些与GTPase控制相关的调节元件连接。病原体利用GTPase功能的这些改变实现多种功能，包括杀死宿主细胞，介导细菌进入宿主细胞（入侵），重编程肌动蛋白以在宿主细胞中形成附着细菌的损伤，通过影响细胞内运输介导细胞内存活，或提供聚合肌动蛋白机制以推动宿主细胞内的微生物进入邻近细胞。总的来说，这些例子代表了许多关键的微生物毒力机制，这些机制使人们对微生物病原体和GTPase功能有了更深入的了解。
The ability to modify central host cellular functions is a major advantage to many bacterial pathogens that use such strategies as part of their virulence mechanisms. Small GTPases, including Rho GTPases, make particularly attractive targets for pathogens because of their central roles in modulating cellular functions such as cytoskeletal control. Such modifications of these GTPases can include direct chemical modification of the GTPase or interfacing with some of the regulatory elements associated with GTPase control. Pathogens use these alterations in GTPase functions for a variety of functions, including killing the host cell, mediating bacterial uptake into the host cell (invasion), reprogramming actin to form a lesion in host cells underlying adherent bacteria, to mediate intracellular survival by affecting intracellular trafficking, or to provide polymerized actin mechanisms to propel microbes around inside host cells and into adjacent cells. Collectively, these examples represent many key microbial virulence mechanisms that have led to a much deeper understanding of both microbial pathogens and GTPase functions.
DOI：
10.1073/pnas.97.16.8754
发表时间：
2000-08-01
影响因子：
11.1
作者：
Galán, JE;Zhou, D
通讯作者：
Zhou, D