Comparison of Isotonic Designs for Dose-Finding
Comparison of Isotonic Designs for Dose-Finding
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DOI：
10.1198/sbr.2009.0010
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发表时间：
2009-02-01
影响因子：
1.8
通讯作者：
Flournoy, Nancy
中科院分区：
文献类型：
--
作者：
Ivanova, Anastasia;Flournoy, Nancy
我们比较了几个决策规则分配受试者的剂量是基于连续等渗估计的单调剂量-毒性曲线。我们的结论是，决策规则，其中的下一个分配是最接近目标的毒性概率的剂量不工作。在我们的比较中，最好的规则是通过累积队列设计给出的。根据该设计，根据当前剂量下估计的毒性率与目标分位数之间的距离，降低、增加或重复下一名受试者的剂量。
We compare several decision rules for allocating subjects to dosages that are based on sequential isotonic estimates of a monotone dose-toxicity curve. We conclude that the decision rule in which the next assignment is to the dose having probability of toxicity closest to target does not work well. The best rule in our comparison is given by the cumulative cohort design. According to this design, the dose for the next subject is decreased, increased, or repeated depending on the distance between the estimated toxicity rate at the current dose and the target quantile.