Association between Body Mass Index and Risk of Gastric Cancer by Anatomic and Histologic Subtypes in Over 500,000 East and Southeast Asian Cohort Participants.
Association between Body Mass Index and Risk of Gastric Cancer by Anatomic and Histologic Subtypes in Over 500,000 East and Southeast Asian Cohort Participants.
复制标题
DOI：
10.1158/1055-9965.epi-22-0051
复制
发表时间：
2022-09-02
影响因子：
3.8
通讯作者：
Park, Sue K.
中科院分区：
文献类型：
--
作者：
Jang, Jieun;Lee, Sangjun;Ko, Kwang-Pil;Abe, Sarah K.;Rahman, Md. Shafiur;Saito, Eiko;Islam, Md. Rashedul;Sawada, Norie;Shu, Xiao-Ou;Koh, Woon-Puay;Sadakane, Atsuko;Tsuji, Ichiro;Kim, Jeongseon;Oze, Isao;Nagata, Chisato;Tsugane, Shoichiro;Cai, Hui;Yuan, Jian-Min;Gao, Yu-Tang;Ozasa, Kotaro;Matsuyama, Sanae;Kanemura, Seiki;Shin, Aesun;Ito, Hidemi;Wada, Keiko;Sugawara, Yumi;Chen, Yu;Ahsan, Habibul;Boffetta, Paolo;Chia, Kee Seng;Matsuo, Keitaro;Qiao, You-Lin;Rothman, Nathaniel;Zheng, Wei;Inoue, Manami;Kang, Daehee;Park, Sue K.
本研究旨在调查东亚和东南亚的体重指数 (BMI) 与胃癌 (GC) 之间的关联，这些地区的 GC 大部分为非贲门 GC。基于来自中国、日本、韩国和新加坡的亚洲队列联盟参与者 (N=538,835) 的 8,997 例 GC 病例，我们通过使用 Cox 比例风险回归模型计算风险比 (HR) 和 95% 置信区间 (CI)，根据 BMI 评估 GC 风险。观察到 BMI 和 GC 风险之间存在 U 形关联。体重不足组（<18.5 kg/m2）和肥胖组（≥27.5 kg/m2）的GC风险高于参考BMI组（23-24.9 kg/m2）（体重不足HR=1.15，95% CI 1.05-1.25；肥胖HR=1.12，95% CI 1.03-1.22）。在非贲门型 GC、肠型 GC 和晚发型 GC 的分析中，体重不足和肥胖与 GC 风险的关联是一致的。未观察到体重不足和肥胖与贲门 GC、弥漫型 GC 和早发型 GC 风险之间存在显着关联。此外，我们发现，在非吸烟者中，BMI 和 GC 风险之间仍然存在 U 形关联，而在吸烟者中，只有体重过轻与 GC 风险增加相关。在东亚和东南亚人群中，BMI 与 GC 风险呈 U 形相关，尤其是非贲门型 GC、肠型 GC 和迟发性 GC。未来的研究需要考虑GC的解剖位置和组织学，以确定体重不足和肥胖与GC风险之间的关联。
This study was performed to investigate the association between body mass index (BMI) and gastric cancer (GC) in East and Southeast Asia where most of GC is non-cardia GC. Based on 8,997 GC cases among the Asia Cohort Consortium participants from China, Japan, Korea, and Singapore (N=538,835), we assessed GC risk according to BMI by calculating hazard ratios (HRs) and 95% confidence intervals (CIs) using the Cox proportional hazard regression model. A U-shaped associations between BMI and GC risk were observed. GC risks in underweight group (<18.5 kg/m2) and in obesity group (≥27.5 kg/m2) were higher than reference BMI group (23–24.9 kg/m2) (HR=1.15, 95% CI 1.05–1.25 for underweight; HR=1.12, 95% CI 1.03–1.22 for obesity, respectively). The associations of underweight and obesity with GC risk were consistent in the analyses for non-cardia GC, intestinal type GC, and late onset GC. No significant association of underweight and obesity with the risk of cardia GC, diffuse type GC, and early onset GC was observed. Additionally, we found that the U-shaped association between BMI and GC risk remained in non-smokers, while only underweight was related to increased GC risk in smokers. BMI has a U-shaped association with GC risk in East and Southeast Asian population, especially for the non-cardia GC, intestinal type GC, and late onset GC. Future studies with consideration of anatomical location and histology of GC are needed to establish the association of underweight as well as obesity with GC risk.