Does edaravone (MCI-186) act as an antioxidant and a neuroprotector in experimental traumatic brain injury?
Does edaravone (MCI-186) act as an antioxidant and a neuroprotector in experimental traumatic brain injury?
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DOI：
10.1089/ars.2007.9.281
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发表时间：
2007-02-01
影响因子：
6.6
通讯作者：
Aruga, Tohru
中科院分区：
文献类型：
--
作者：
Dohi, Kenji;Satoh, Kazue;Aruga, Tohru
依达拉奉（MCI-186）是一种新型的自由基清除剂，具有神经保护作用。目前用于脑梗死患者。在这里，我们注意到依达拉奉在大鼠实验性创伤性脑损伤中的有益药物作用。在特定的实验条件下，依达拉奉作为一种合成的抗氧化剂，最大限度地减少了创伤性脑损伤。临床试验测试依达拉奉的疗效是必要的。
Edaravone (MCI-186) is a novel synthetic free radical scavenger intended to have neuroprotective effect against ischemic insult. It is currently used on patients with cerebral infarction. Here, we note beneficial pharmaceutical effects of edaravone in rat experimental traumatic brain injury. Under specific experimental conditions, edaravone minimized traumatic brain injury by functioning as a synthetic antioxidant. Clinical trials testing the efficacy of edaravone are warranted.