Detection of gas components as a novel diagnostic method for colorectal cancer
Detection of gas components as a novel diagnostic method for colorectal cancer
复制标题
DOI：
10.1002/ags3.12056
复制
发表时间：
2018-03-01
影响因子：
2.7
通讯作者：
Endo, Itaru
中科院分区：
文献类型：
--
作者：
Ishibe, Atsushi;Ota, Mitsuyoshi;Endo, Itaru
背景：粪便潜血检查（FOBT）是目前公认的最经济、无创的结直肠癌筛查方法。然而，FOBT是不方便的，因为它需要粪便样本和显示有限的准确性。或者，我们假设排便产生的粪便化合物可能是结直肠癌的非侵入性生物标志物。方法：从30例结直肠癌患者和26例健康对照者的肠蠕动中收集气体化合物。患者组男性17例，女性13例，平均年龄68岁。此外，22名患者患有结肠癌，8名患者患有直肠癌。用气相色谱法分析气体化合物，并与健康对照进行比较。结果：在气体分析中，结直肠癌组的甲基硫醇明显高于对照组。结直肠癌组的氢含量明显低于对照组，且与肿瘤深度和疾病分期相关。鉴别式检测的灵敏度为90%，特异度为57.7%，准确度为75%。结论：排便气体化合物是一种很有前景的、新型的、无创的CRC筛查方法。
Background: The fecal occult blood test (FOBT) is widely accepted as the most economic and non-invasive screening method for colorectal cancer (CRC). However, the FOBT is inconvenient because it requires a fecal sample and shows limited accuracy. Alternatively, we hypothesized that fecal gas compounds from bowel movements may be a non-invasive biomarker for CRC.Methods: Gas compounds were collected from the bowel movements of 30 patients with CRC and from 26 healthy controls. The patient group comprised 17 males and 13 females, and the average age was 68 years. Additionally, 22 patients had colon cancer, and eight patients had rectal cancer. Gas compounds were analyzed using gas chromatography and compared with those from healthy controls.Results: In the gas analysis, methyl mercaptan was significantly higher in the CRC group than in the control group. Hydrogen was significantly lower in the CRC group than in the control group and was correlated with tumor depth and advanced disease stage. Sensitivity, specificity, and accuracy of detection by a discriminant formula were 90%, 57.7%, arid 75%, respectively.Conclusion: Gas compounds from defecation constitute a promising, novel non-invasive approach for CRC screening.