Prognostic significance of p53 nuclear overexpression in patients of muscle invasive urinary bladder carcinoma treated with cystectomy
Prognostic significance of p53 nuclear overexpression in patients of muscle invasive urinary bladder carcinoma treated with cystectomy
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DOI：
10.1159/000067703
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发表时间：
2003-01-01
影响因子：
1.6
通讯作者：
Nabi, G
中科院分区：
文献类型：
--
作者：
Hemal, AK;Khaitan, A;Nabi, G
简介：本研究的目的是确定接受膀胱切除术治疗的肌层浸润性膀胱癌患者中 p53 的表达模式，并评估 p53 表达在该组患者中的预后价值。 材料与方法：我们回顾性分析了 100 例因膀胱浸润性移行细胞癌接受膀胱切除术的患者的数据。这些患者在前 2 年每 3 个月一次，第三年每 6 个月一次，此后每年一次。使用 DO-7 抗体对石蜡固定的组织进行 p53 的免疫组织化学分析。 p53蛋白染色>30%的细胞被认为是p53阳性的肿瘤。结果：有95名男性和5名女性，平均年龄54岁。两名患者在围手术期死亡并被排除在分析之外。中位随访期为 2 年（范围为 3 个月至 10 年），62 名患者无病生存，36 名患者病情复发，其中 31 名患者死亡。 p53表达与肿瘤的分期和分级显着相关。与 p53 阳性肿瘤相比，p53 阴性肿瘤更有可能局限于器官且级别较低。肿瘤分期与结果显着相关，但分级和p53免疫组化不能提供任何预后信息。结论：57%的肌层浸润性膀胱肿瘤p53免疫染色呈阳性。 p53 阳性与疾病的阶段和分级密切相关，但没有额外的预后价值。版权所有 (C) 2003 S. Karger AG，巴塞尔。
Introduction: The objective of the study was to determine the pattern of p53 expression in patients with muscle invasive bladder cancer treated with cystectomy and to assess the prognostic value of p53 expression in this group of patients.Materials and Methods: We retrospectively analyzed data of 100 patients who underwent cystectomy for invasive transitional cell carcinoma of the urinary bladder. These patients were seen at 3-monthly intervals during the first 2 years, 6-monthly in the third year, and yearly thereafter. Immunohistochemical analysis for p53 was done on paraffin-fixed tissues with DO-7 antibodies. The tumours with >30% cells staining for p53 proteins were considered p53 positive.Results: There were 95 males and 5 females with a mean age of 54 years. Two patients died in the perioperative period and were excluded from analysis. Over a median follow-up period of 2 years (range 3 months to 10 years) 62 patients are alive without disease while 36 had relapse and of these, 31 have died. The p53 expression was significantly related to stage and grade of the tumour. p53-negative tumours were more likely to be organ confined and of lower grade as compared to p53-positive tumours. The stage of tumour was significantly related to outcome but grade and p53 immunohistochemistry did not provide any prognostic information.Conclusions: p53 immunostaining was positive in 57% of muscle invasive urinary bladder tumours. The p53 positivity correlated well with the stage and grade of the disease, whereas it has no additional prognostic value. Copyright (C) 2003 S. Karger AG, Basel.