Retinol concentration in maternal and cord serum: its relation to birth weight in healthy mother-infant pairs
Retinol concentration in maternal and cord serum: its relation to birth weight in healthy mother-infant pairs
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DOI：
10.1016/s0378-3782(02)00096-8
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发表时间：
2003-02-01
影响因子：
2.5
通讯作者：
Gorodischer, R
中科院分区：
文献类型：
--
作者：
Gazala, E;Sarov, B;Gorodischer, R
背景：维生素A是胎儿发育和生长所必需的微量营养素。本研究的目的是确定低血清视黄醇和出生体重在以色列南部的健康母婴对之间的可能关联。次要目的是检查母体和脐带血清视黄醇的种族差异。方法：对健康母亲和健康足月新生儿进行分娩时血清视黄醇测定。结果：在研究的313对母婴中，56%是犹太人，44%是贝都因人。与血清视黄醇正常的母亲（大于或等于0.7 mumol/l）相比，血清视黄醇较低的母亲（< 0.7 mumol/l）的婴儿出生体重在2500-2999 g之间的比例更大（p < 0.001）。与出生体重大于或等于3000 g的婴儿相比，出生体重为2500-2990 g的婴儿中脐带视黄醇< 0.7 mumol/l的发生率更高（p = 0.006）。使用分裂模型和逐步多元回归分析，婴儿的出生体重显着影响脐带视黄醇浓度低血清视黄醇的母亲所生的婴儿，胎龄和脐带视黄醇单独解释了27%的出生体重的变异在这组。贝都因婴儿血清视黄醇< 0.7和< 0.35 mumol/l的比例高于犹太婴儿（均为p < 0.001）。结论：脐带和母体血清视黄醇含量低可能反映了新生儿和母亲的维生素A状况较差，这反过来又可能影响胎儿生长。(C)2002爱思唯尔科学爱尔兰有限公司保留所有权利。
Background: Vitamin A is an essential micronutrient for the development and growth of the fetus. The objective of this study was to identify a possible association between low serum retinol and birth weight in healthy mother-infant pairs in Southern Israel. A secondary objective was to examine ethnic differences in maternal and cord serum retinol. Methods: Serum retinol was measured at delivery from pairs of healthy mothers and healthy mature newborns. Results: Of the 313 mother-infant pairs studied, 56% were Jews and 44% Bedouins. The proportion of infants with birth weight of 2500-2999 g was greater among mothers with lower serum retinol (< 0.7 mumol/l) compared to mothers with normal serum retinol (greater than or equal to 0.7 mumol/l) (p < 0.001). Cord retinol < 0.7 mumol/l was more frequent in infants with birth weight 2500-2990 g compared to infants with birth weight greater than or equal to 3000 g (p = 0.006). Using a split model and stepwise multiple regression analysis, infant's birth weight was significantly influenced by cord retinol concentration in infants born to mothers with low serum retinol; gestational age and cord retinol alone explained 27% of the variability of birth weight in this group. A higher proportion of Bedouin than Jewish infants had serum retinol < 0.7 and < 0.35 mumol/l (both p < 0.001). Conclusion: Low cord and maternal serum retinol may reflect poor vitamin A status of the newborn and the mother, which in turn may affect fetal growth. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.