High serum matrix metalloproteinase-9 level predict increased risk of in-hospital cardiac events in patients with type 2 diabetes and ST segment elevation myocardial infarction
High serum matrix metalloproteinase-9 level predict increased risk of in-hospital cardiac events in patients with type 2 diabetes and ST segment elevation myocardial infarction
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DOI：
10.1016/j.atherosclerosis.2006.11.012
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发表时间：
2008-01-01
期刊：
影响因子：
5.3
通讯作者：
Kaski, Juan Carlos
中科院分区：
文献类型：
--
作者：
Dominguez-Rodriguez, Alberto;Abreu-Gonzalez, Pedro;Kaski, Juan Carlos
简介：本研究的目的是比较因 ST 段抬高型心肌梗死 (STEMI) 住院的 2 型糖尿病患者与非糖尿病患者的血清基质金属蛋白酶 (MMP)-9 水平，并检查血清 MMP-9 水平与院内心脏事件（包括死亡和心源性休克）发生率之间的关系。方法：我们招募了 120 名 STEMI 患者，其中 48 名是 2 型糖尿病患者，72 名患者是 2 型糖尿病患者。非糖尿病。入院时使用市售 ELISA 测量血清 MMP-9 水平。主要研究终点是院内心源性死亡和心源性休克。结果：与非糖尿病患者相比，2 型糖尿病患者的平均血清 MMP-9 水平显着较高（240 +/- 52 ng/mL 对比 185 +/- 47 ng/mL；P < 0.0001）。在多变量分析中，2型糖尿病是死亡率的独立因素[OR：1.75（1.40-2.30）； P = 0.005]和心源性休克[OR：1.55（1.20-1.70）； P = 0.03]当变量MMP-9水平没有引入模型时，但它与死亡率的相关性不太显着[OR：1.60（1.40-2.10）； P = 0.01]并且当模型中存在MMP-9时不再与心源性休克相关。结论：STEMI后，2型糖尿病与高血清MMP-9水平独立相关。这种升高的 MMP-9 与 2 型糖尿病中观察到的院内死亡率和心源性休克发生率增加密切相关。我们的研究结果清楚地表明，血清 MMP-9 为 STEMI 后的院内结局（尤其是 2 型糖尿病患者）提供了非常有价值的预后信息。 (C) 2006 Elsevier Ireland Ltd. 保留所有权利。
Introduction: The purpose of this study was to compare serum matrix metalloproteinase (MMP)-9 levels in a population of type 2 diabetic versus non-diabetic patients hospitalized with ST-segment elevation myocardial infarction (STEMI) and to examine the relationship between serum MMP-9 levels and the incidence of in-hospital cardiac events, including death and cardiogenic shock.Methods: We recruited 120 patients with STEMI, of whom 48 were type 2 diabetic and 72 non-diabetic. Serum MMP-9 levels were measured on admission, using a commercially available ELISA. The primary study endpoint was cardiac death in-hospital and cardiogenic shock.Results: Mean serum MMP-9 levels were significantly higher in type 2 diabetic patients compared to non-diabetic patients (240 +/- 52 ng/mL versus 185 +/- 47 ng/mL; P < 0.0001). In multivariable analysis, type 2 diabetes was an independent factor for mortality [OR: 1.75 (1.40-2.30); P = 0.005] and cardiogenic shock [OR: 1.55 (1.20-1.70); P = 0.03] when the variable MMP-9 level was not introduced into the model, but it was less significantly associated with mortality [OR: 1.60 (1.40-2. 10); P = 0.01] and no longer associated with cardiogenic shock when MMP-9 was in the model.Conclusion: After STEMI, type 2 diabetes is independently associated with high serum MMP-9 levels. This elevated MMP-9 is strongly associated with the increased incidence of in-hospital mortality and cardiogenic shock observed in type 2 diabetes. Our findings clearly indicate that serum MMP-9 provides a highly valuable prognostic information on in-hospital outcome after STEMI, in particular in type 2 diabetic patients. (C) 2006 Elsevier Ireland Ltd. All rights reserved.