Minimal interval defined on 7q in uterine leiomyoma
Minimal interval defined on 7q in uterine leiomyoma
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DOI：
10.1016/j.cancergencyto.2004.06.007
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发表时间：
2005-02-01
影响因子：
--
通讯作者：
Gewin, J
中科院分区：
文献类型：
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作者：
Sell, SM;Tullis, C;Gewin, J
子宫肌瘤是一种良性的、平滑的肿瘤。这种肿瘤非常常见，在美国每年大约有1000-1500万妇女受到影响。子宫肌瘤通常没有症状，但可能会引起严重的症状，从轻微的腹部不适到子宫脱垂。在肿瘤组织中发现了几种不同的染色体异常。由于这种肿瘤的常见发生和相关后遗症的潜在严重性，有必要对不同的分子亚型进行研究。7号染色体长臂上的缺失被认为是子宫肌瘤最常见的遗传异常。缺失的大小各不相同，这使得识别缺失后对肿瘤生长有贡献的基因变得困难。先前定义的最小间隔是>；12,000 kb。我们已经将最小区域缩小到
Uterine leiomyomata are benign, smooth-muscle tumors. The tumors are very common, affecting similar to10-15 million women in the United States annually. Uterine leiornyomata are often asymptomatic, but may cause symptoms that range in severity from mild abdominal discomfort to uterine prolapse. Several different chromosomal aberrations have been found in the tumor tissue. Because of the common occurrence of this tumor and the potential severity of associated sequelae, research delineating the different molecular subtypes is needed. Deletions on the long arm of chromosome 7 are believed to be the most common genetic anomaly in uterine leiomyoma. The size of the deletion varies, which makes it difficult to identify the genes that, upon deletion, contribute to tumor growth. The smallest previously defined interval was > 12,000 kb. We have narrowed a minimal region to an interval of