Satellite Cell Heterogeneity in Skeletal Muscle Homeostasis.
Satellite Cell Heterogeneity in Skeletal Muscle Homeostasis.
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DOI：
10.1016/j.tcb.2016.02.004
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发表时间：
2016-06
影响因子：
19
通讯作者：
Sacco A
中科院分区：
文献类型：
--
作者：
Tierney MT;Sacco A
骨骼肌维持和修复所需的细胞更新是由常驻干细胞（也称为卫星细胞）介导的。卫星细胞通常处于静止状态，间歇性地进入细胞周期与邻近的肌纤维融合并补充干细胞库。然而，卫星细胞维持自我更新和长期稳态所需的分化之间的精确平衡的机制仍不清楚。最近的工作已经支持了以前不受重视的异质性卫星细胞室，可能是观察到的细胞命运和功能的变化。在这篇综述中，我们研究了支持这一概念的工作，以及潜在的管理原则，发展的起源，和卫星细胞异质性的主要决定因素。
The cellular turnover required for skeletal muscle maintenance and repair is mediated by resident stem cells, also termed satellite cells. Satellite cells normally reside in a quiescent state, intermittently entering the cell cycle to fuse with neighboring myofibers and replenish the stem cell pool. However, the mechanisms by which satellite cells maintain the precise balance between self-renewal and differentiation necessary for long-term homeostasis remain unclear. Recent work has supported a previously unappreciated heterogeneity in the satellite cell compartment that may underlie the observed variability in cell fate and function. In this review, we examine the work supporting this notion as well as the potential governing principles, developmental origins, and principal determinants of satellite cell heterogeneity.