INFLUENCE OF AGE AND HEMODYNAMICS ON MYOCARDIAL BLOOD-FLOW AND FLOW RESERVE
INFLUENCE OF AGE AND HEMODYNAMICS ON MYOCARDIAL BLOOD-FLOW AND FLOW RESERVE
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DOI：
10.1161/01.cir.88.1.62
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发表时间：
1993-07-01
期刊：
影响因子：
37.8
通讯作者：
SCHELBERT, HR
中科院分区：
文献类型：
--
作者：
CZERNIN, J;MULLER, P;SCHELBERT, HR
背景资料。衰老与收缩压的改变有关，这可能会增加静息状态下的心脏做功和心肌血流量，减少心肌血流储备。这可能被误解为与年龄相关的冠状动脉血管扩张剂能力受损。用N-13-氨水和正电子发射断层扫描对40名健康志愿者(12名女性和28名男性)在静息状态和静脉注射潘生丁后的心肌血流量进行了定量。18例正常人年龄小于50岁，22例大于50岁(31+/-9岁对+/-9岁)。年轻组静息压乘积低于老年组(6895+/-1070比8634+/-1890；P
Background. Aging is associated with changes of the systolic blood pressure that may increase cardiac work and myocardial blood How at rest and reduce the myocardial flow reserve. This might be misinterpreted as age-related impairment of the coronary vasodilator capacity.Methods and Results. Myocardial blood flow was quantified at rest and after administration of intravenous dipyridamole in 40 healthy volunteers (12 women and 28 men) with N-13-ammonia and positron emission tomography. Eighteen of the normal subjects were less than and 22 were older than 50 years (31+/-9 versus 64+/-9 years). The resting rate-pressure product was lower in the younger than in the older subjects (6895+/-1070 versus 8634+/-1890; P