Investigating temporal and prosodic markers in clinical high-risk for psychosis participants using automated acoustic analysis
Investigating temporal and prosodic markers in clinical high-risk for psychosis participants using automated acoustic analysis
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DOI：
10.1111/eip.13357
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发表时间：
2022-10-07
影响因子：
2
通讯作者：
Uhlhaas, Peter J.
中科院分区：
文献类型：
--
作者：
Bianciardi, Bianca;Gajwani, Ruchika;Uhlhaas, Peter J.
目的语言障碍是早期发现精神病的候选生物标志物。在精神分裂症患者中观察到了时间和韵律异常，而在符合精神病临床高风险（CHR-P）标准的参与者中是否存在此类缺陷则存在相互矛盾的证据。方法对CHR-P参与者（n = 50）的临床访谈进行时间和韵律指标检查，并与一组健康对照组（n = 17）和情感障碍和物质滥用的参与者（n = 23）进行比较。结果CHR-P组的声学参数无明显缺陷，而情感障碍/物质滥用组的语音频率较低，停顿时间较长，清音帧比例较高。结论早期精神病患者言语的时间和韵律方面没有受损。需要进一步的研究来澄清这种异常是否存在于CHR-P参与者中精神病风险升高的亚组中。
Aim Language disturbances are a candidate biomarker for the early detection of psychosis. Temporal and prosodic abnormalities have been observed in schizophrenia patients, while there is conflicting evidence whether such deficits are present in participants meeting clinical high-risk for psychosis (CHR-P) criteria. Methods Clinical interviews from CHR-P participants (n = 50) were examined for temporal and prosodic metrics and compared against a group of healthy controls (n = 17) and participants with affective disorders and substance abuse (n = 23). Results There were no deficits in acoustic variables in the CHR-P group, while participants with affective disorders/substance abuse were characterized by slower speech rate, longer pauses and higher unvoiced frames percentage. Conclusion Our finding suggests that temporal and prosodic aspects of speech are not impaired in early-stage psychosis. Further studies are required to clarify whether such abnormalities are present in sub-groups of CHR-P participants with elevated psychosis-risk.