Preliminary Examination of the Toxicity of Spalting Fungal Pigments: A Comparison between Extraction Methods.
Preliminary Examination of the Toxicity of Spalting Fungal Pigments: A Comparison between Extraction Methods.
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DOI：
10.3390/jof7020155
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发表时间：
2021-02-22
期刊：
影响因子：
--
通讯作者：
Robinson SC
中科院分区：
文献类型：
--
作者：
Almurshidi BH;Van Court RC;Vega Gutierrez SM;Harper S;Harper B;Robinson SC
从绿色能源生产到天然着色剂，溅射真菌色素已显示出潜力。然而，它们未知的毒性一直是工业采用的障碍。为了了解色素的安全性，将斑马鱼胚胎暴露于多种形式的液体培养基和溶剂提取的色素中，纯化色素的浓度范围为0至50 mM，来自绿石藻、绿石藻和Scytalidium cuboideum。从Chlorociboria sp.中纯化的木茚定素在任何测试浓度下均未显示毒性，而从S. cuboideum仅与高于23.2 μ M的显著毒性相关。然而，液体培养物和提取到二氯甲烷（DCM）中的色素显示出毒性，表明生物活性次级代谢产物的共同生产。未来对红色dramada色素的纯化和生物利用度的研究对于确定适当的用途将是重要的;然而，蓝绿色色素木茚定的纯化形式可能对跨行业使用是安全的。这为采用基于这些颜料的绿色技术打开了大门，有可能取代合成着色剂和不太稳定的天然颜料。
Spalting fungal pigments have shown potential in technologies ranging from green energy generation to natural colorants. However, their unknown toxicity has been a barrier to industrial adoption. In order to gain an understanding of the safety of the pigments, zebrafish embryos were exposed to multiple forms of liquid media and solvent-extracted pigments with concentrations of purified pigment ranging from 0 to 50 mM from Chlorociboria aeruginosa, Chlorociboria aeruginascens, and Scytalidium cuboideum. Purified xylindein from Chlorociboria sp. did not show toxicity at any tested concentration, while the red pigment dramada from S. cuboideum was only associated with significant toxicity above 23.2 uM. However, liquid cultures and pigment extracted into dichloromethane (DCM) showed toxicity, suggesting the co-production of bioactive secondary metabolites. Future research on purification and the bioavailability of the red dramada pigment will be important to identify appropriate use; however, purified forms of the blue-green pigment xylindein are likely safe for use across industries. This opens the door to the adoption of green technologies based on these pigments, with potential to replace synthetic colorants and less stable natural pigments.
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影响因子：
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作者：
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作者：
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通讯作者：
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