A study on the regio- and stereoselectivity in palladium-catalyzed cyclizations of alkenes and alkynes bearing bromoaryl and nucleophilic groups
A study on the regio- and stereoselectivity in palladium-catalyzed cyclizations of alkenes and alkynes bearing bromoaryl and nucleophilic groups
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DOI：
10.1016/j.tet.2004.03.023
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发表时间：
2004-04-26
期刊：
影响因子：
2.1
通讯作者：
Balme, G
中科院分区：
文献类型：
--
作者：
Bruyère, D;Bouyssi, D;Balme, G
我们已经研究了显着的依赖性的立体化学的环化的双键的几何形状和影响的庞大的亲核试剂的区域化学的钯介导的环化的烯烃轴承芳基溴和亲核试剂。相反。炔属同源底物的环化不依赖于亲核试剂的性质。(C)2004爱思唯尔有限公司保留所有权利。
We have studied the remarkable dependence of the stereochemistry of the cyclization on the double bond geometry and of the effect of the bulkiness of the nucleophile on the regiochemistry of the palladium mediated cyclization of alkenes bearing aryl bromides and nucleophiles. In contrast. the cyclization of the acetylenic homologous substrates is not dependent on the nature of the nucleophile. (C) 2004 Elsevier Ltd. All rights reserved.