Ethnic differences in diffuse noxious inhibitory controls
Ethnic differences in diffuse noxious inhibitory controls
复制标题
DOI：
10.1016/j.jpain.2008.03.010
复制
发表时间：
2008-08-01
期刊：
影响因子：
4
通讯作者：
Fillingim, Roger B.
中科院分区：
文献类型：
--
作者：
Campbell, Claudia M.;France, Christopher R.;Fillingim, Roger B.
大量证据表明，不同种族群体的临床和实验疼痛体验有所不同。具体来说，非裔美国人通常报告更高水平的临床疼痛和更大的敏感性实验诱导的疼痛;然而，很少有研究探讨了这些差异的起源。中枢疼痛抑制机制的差异可能导致这种差异。弥漫性伤害性抑制控制（DNIC）或反刺激，是一种被认为反映疼痛信号下行抑制的现象。目前的研究评估了来自两个不同种族的57名健康年轻人的DNIC：非洲裔美国人和非西班牙裔白人。在缺血性手臂疼痛手术（以及假手术）之前、期间和之后重复评估伤害性屈曲反射（NFR）以及电疼痛评级。与假手术组相比，DNIC条件（即缺血性手臂疼痛）使所有参与者的疼痛评分以及NFR的电生理测量显著降低（P < .001）。与非裔美国人相比，DNIC条件下非西班牙裔白人的言语疼痛评分显著降低（P = 0.02），而种族组的NFR降低幅度相当。这项研究的结果表明，非洲裔美国人和非西班牙裔白人之间的内源性疼痛抑制的差异，并进一步研究，以确定这些影响的机制是必要的。观点：这项研究增加了越来越多的文献研究种族差异的实验疼痛感知。我们的数据表明，这些变化可能受到下行抑制差异的影响。(c)2008年，美国疼痛协会。
Substantial evidence indicates that the experience of both clinical and experimental pain differs among ethnic groups. Specifically, African Americans generally report higher levels of clinical pain and greater sensitivity to experimentally induced pain; however, little research has examined the origins of these differences. Differences in central pain-inhibitory mechanisms may contribute to this disparity. Diffuse noxious inhibitory controls (DNIC), or counterirritation, is a phenomenon thought to reflect descending inhibition of pain signals. The current study assessed DNIC in 57 healthy young adults from 2 different ethnic groups: African Americans and non-Hispanic whites. Repeated assessments of the nociceptive flexion reflex (NFR) as well as ratings of electrical pain were obtained before, during, and after an ischemic arm pain procedure (as well as a sham procedure). The DNIC condition (ie, ischemic arm pain) produced substantial reductions in pain ratings as well as electrophysiologic measures of the NFR for all participants when compared with the sham condition (P < .001). The DNIC condition produced significantly greater reductions in verbal pain ratings among non-Hispanic whites when compared with African Americans (P = .02), whereas ethnic groups showed comparable reductions in NFR. The findings of this study suggest differences in endogenous pain inhibition between African Americans and non-Hispanic whites and that additional research to determine the mechanisms underlying these effects is warranted. Perspective: This study adds to the growing literature examining ethnic differences in experimental pain perception. Our data suggest that these variations may be influenced by differences in descending inhibition. (c) 2008 by the American Pain Society.