Evidence for two psoriasis susceptibility loci (HLA and 17q) and two novel candidate regions (16q and 20p) by genome-wide scan
Evidence for two psoriasis susceptibility loci (HLA and 17q) and two novel candidate regions (16q and 20p) by genome-wide scan
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DOI：
10.1093/hmg/6.8.1349
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发表时间：
1997-08-01
影响因子：
3.5
通讯作者：
Elder, JT
中科院分区：
文献类型：
--
作者：
Nair, RP;Henseler, T;Elder, JT
在银屑病易感基因座的12.5 cM全基因组扫描中，基于重组的测试显示与HLA区域（Z（max）= 3.52）的连锁，以及与两个新区域的暗示性连锁：16号染色体（60-83.1 cM，Z（max）= 2.50），染色体20 p（距pter 7.5-25 cM，Z（max）= 2.62），通过非参数分析，所有三个区域产生的P值均小于或等于0.01，基于等位基因共享的方法也证实了先前关于染色体17 q远端上的显性易感基因座的报道（108.2cM，Z（max）= 2.09，GENEHUNTER P = 0.0056），我们不能证实先前报道的位于染色体远端4 q的基因座;然而，在该位点附近发现了一个意义不明的广泛区域（153.6-178.4 cM，来自pter，Z（max）= 1.01），结合我们最近的结果表明与HLA-B和-C的连锁，该全基因组扫描鉴定了HLA处的银屑病易感性位点，证实了与17 q的连锁，并推荐了两个新的基因组区域用于进一步的审查。这些区域之一（16 q）与最近确定的克罗恩病易感基因座重叠，Psb在克罗恩病患者中比对照组中更常见，这表明能够影响两种疾病的免疫调节基因座可能位于该区域。
In a 12.5 cM genome-wide scan for psoriasis susceptibility loci, recombination-based tests revealed linkage to the HLA region (Z(max) = 3.52), as well as suggestive linkage to two novel regions: chromosome 16q (60-83.1 cM from pter, Z(max) = 2.50), and chromosome 20p (7.5-25 cM from pter, Z(max) = 2.62), All three regions yielded P values less than or equal to 0.01 by non-parametric analysis, Recombination-based and allele sharing methods also confirmed a previous report of a dominant susceptibility locus on distal chromosome 17q (108.2 cM from pter, Z(max) = 2.09, GENEHUNTER P = 0.0056), We could not confirm a previously reported locus on distal chromosome 4q; however, a broad region of unclear significance was identified proximal to this proposed locus (153.6-178.4 cM from pter, Z(max) = 1.01), Taken together with our recent results demonstrating linkage to HLA-B and -C, this genome-wide scan identifies a psoriasis susceptibility locus at HLA, confirms linkage to 17q, and recommends two novel genomic regions for further scrutiny. One of these regions (16q) overlaps with a recently-identified susceptibility locus for Crohn's disease, Psoriasis is much more common in patients with Crohn's disease than in controls, suggesting that an immunomodulatory locus capable of influencing both diseases may reside in this region.