Magnetic resonance imaging in familial versus sporadic cases of schizophrenia.
Magnetic resonance imaging in familial versus sporadic cases of schizophrenia.
复制标题
家族性与散发性精神分裂症病例的磁共振成像。
DOI：
10.1016/0165-1781(94)90062-0
复制
发表时间：
1994
影响因子：
11.3
通讯作者：
Andreasen,NC
中科院分区：
文献类型：
--
作者：
Roy,MA;Flaum,MA;Arndt,SV;Crowe,RR;Andreasen,NC
本文比较了22例家族性和29例散发性精神分裂症、情感性精神分裂症或精神分裂样精神障碍患者的磁共振成像表现。体积测量用于评估脑结构的大小，包括颅骨、大脑、侧脑室、颞角、第三脑室、豆状核、杏仁-海马复合体和小脑，以及侧脑室的不对称性。与散发病例和正常对照组相比，家族性病例的豆状核体积增加，心室不对称性增加（左心室较大）。豆状核体积增大和侧脑室不对称性增大可能反映了遗传因素在精神分裂症中的作用。
Magnetic resonance imaging findings were compared in 22 familial and 29 sporadic cases withDSM-III-Rdiagnosis of schizophrenia, schizoaffective, or schizophreniform disorders. Volumetric measurements were used to assess the size of brain structures, including the cranium, cerebrum, lateral ventricles, temporal horns, third ventricle, lenticular nuclei, amygdaloid-hippocampal complex, and cerebellum, as well as the asymmetry of the lateral ventricles. Increased volume of the lenticular nuclei and greater ventricular asymmetry (the left ventricle being larger) were found in familial cases compared with sporadic cases and normal control subjects. It is possible that increased lenticular nuclei volume and greater lateral ventricular asymmetry reflect the role of genetic factors in schizophrenia.