Functional Heterogeneity and Convergence in the Right Temporoparietal Junction.
Functional Heterogeneity and Convergence in the Right Temporoparietal Junction.
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DOI：
10.1093/cercor/bhu292
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发表时间：
2016-03
期刊：
影响因子：
3.7
通讯作者：
S. Lee;G. McCarthy
中科院分区：
文献类型：
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作者：
S. Lee;G. McCarthy
右侧顶叶交界处(RTPJ)负责操纵生物运动处理、心理归因理论和注意力重定向的任务。这些任务引发的激活的接近引发了这样一个问题：这些任务是否共享共同的认知成分过程，而这些过程是由共同的神经底物辅助的。在这里，我们在受试者内部的设计中使用了高分辨率的全脑功能磁共振成像来确定这些任务是否激活了rTPJ的共同区域。在相同的成像过程中，每个参与者都被呈现了3项任务。在一项全脑分析中，我们发现，所有三项任务都只激活了右侧和左侧的TPJ。多体素模式分析表明，重叠区域仍然可以区分这3个任务。值得注意的是，我们在右侧TPJ发现了显著的跨任务分类，这表明三个任务之间存在共同的神经过程。综上所述，这些结果支持先前的研究，这些研究表明rTPJ内的功能异质性，但也表明在重叠区域内功能的收敛。这些结果还要求进一步研究在该重叠区域中所服从的功能的性质。
The right temporoparietal junction (rTPJ) is engaged by tasks that manipulate biological motion processing, Theory of Mind attributions, and attention reorienting. The proximity of activations elicited by these tasks raises the question of whether these tasks share common cognitive component processes that are subserved by common neural substrates. Here, we used high-resolution whole-brain functional magnetic resonance imaging in a within-subjects design to determine whether these tasks activate common regions of the rTPJ. Each participant was presented with the 3 tasks in the same imaging session. In a whole-brain analysis, we found that only the right and left TPJs were activated by all 3 tasks. Multivoxel pattern analysis revealed that the regions of overlap could still discriminate the 3 tasks. Notably, we found significant cross-task classification in the right TPJ, which suggests a shared neural process between the 3 tasks. Taken together, these results support prior studies that have indicated functional heterogeneity within the rTPJ but also suggest a convergence of function within a region of overlap. These results also call for further investigation into the nature of the function subserved in this overlap region.