Efficacy and Safety of Concentrated Growth Factor Fibrin on the Extraction of Mandibular Third Molars: A Prospective, Randomized, Double-Blind Controlled Clinical Study
Efficacy and Safety of Concentrated Growth Factor Fibrin on the Extraction of Mandibular Third Molars: A Prospective, Randomized, Double-Blind Controlled Clinical Study
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浓缩生长因子纤维蛋白拔除下颌第三磨牙的有效性和安全性：一项前瞻性、随机、双盲对照临床研究
DOI：
10.1016/j.joms.2021.10.005
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发表时间：
2022-04-01
影响因子：
1.9
通讯作者：
Long, Zhangbiao
中科院分区：
文献类型：
--
作者：
Fang, Dongdong;Li, Dan;Long, Zhangbiao
目的：探讨浓缩生长因子纤维蛋白（CGF）用于下颌第三磨牙拔除的有效性和安全性。患者和方法：这是一项随机、双盲、对照的临床研究。将行下颌阻生牙拔除术的患者随机分为2组。CGF组利用拔牙窝放置CGF凝胶。在对照组中，窝填充血清。观察术后24周的视觉模拟评分（VAS）、肿胀和牙关紧闭的减少情况、术后干槽症的发生率、第二磨牙的远端牙周深度和骨再生情况以及拔牙窝的骨密度（BMD）。两组之间的基线临床特征无显著差异。术后2、24、48 h CGF组疼痛评分明显低于对照组。两组之间在肿胀或牙关紧闭的减少方面没有显著差异。CGF组无1例发生干槽症，对照组3例发生干槽症。CGF牙槽窝植入后的牙周探诊深度和第二磨牙的骨再生情况均优于自然愈合组（P <0.05）。术后24周各组骨密度均显著增加，但组间差异有统计学意义（P <0.05）。结论：CGF能有效减轻反应性拔牙疼痛，有助于避免干槽症。它能促进牙周组织和骨愈合的远端和拔牙窝。(C)2021年美国口腔颌面外科医师协会。
Purpose: To investigate the efficacy and safety of concentrated growth factor fibrin (CGF) for the extraction of mandibular third molars.Patients and Methods: This was a randomized, double-blind, and controlled clinical study. Patients who underwent mandibular impacted tooth extraction were randomly divided into 2 groups. In the CGF group, the tooth extraction fossa was utilized to place CGF gel. In the control group, the fossa was filled with serum. The visual analogue scale (VAS), reductions in swelling and trismus, incidence of postoperative dry socket, distal periodontal depth and bone regeneration of the second molar, and bone density (BMD) of the extraction fossa at 24 weeks were evaluated.Results: One hundred eighteen patients were enrolled in this study. There was no significant difference in baseline clinical characteristics between the 2 groups. The pain score of the CGF group was significantly lower than that of the control group at 2, 24, and 48 hours after operation. There was no significant difference in the reduction in swelling or trismus between the 2 groups. There were no cases of dry socket in the CGF group and 3 cases of dry socket in the control group. The periodontal probing depth and bone regeneration of the second molar when the socket was implanted with CGF were better than those that healed naturally (P < .05). The bone mineral density of each group was significantly increased at 24 weeks but was significantly different between groups (P < .05).Conclusion: CGF can effectively reduce reactive tooth extraction pain and help avoid dry sockets. It can promote periodontal tissue and bone healing in distal and extracted sockets. (C) 2021 The American Association of Oral and Maxillofacial Surgeons.