Polycystic kidney disease: genes, proteins, animal models, disease mechanisms and therapeutic opportunities
Polycystic kidney disease: genes, proteins, animal models, disease mechanisms and therapeutic opportunities
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DOI：
10.1111/j.1365-2796.2006.01743.x
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发表时间：
2007-01-01
影响因子：
11.1
通讯作者：
Harris, P. C.
中科院分区：
文献类型：
--
作者：
Torres, V. E.;Harris, P. C.
对导致多囊肾病发展的遗传、分子和细胞机制的进一步了解为合理疗法的开发奠定了基础。目前有许多动物模型可以测试这些疗法。本文综述了这些治疗的基本原理，临床前试验的结果和临床试验的前景，一些已经在实施的早期阶段。
An increased understanding of the genetic, molecular and cellular mechanisms responsible for the development of polycystic kidney disease has laid out the foundation for the development of rational therapies. Many animal models where these therapies can be tested are currently available. This review summarizes the rationale for these treatments, the results of preclinical trials and the prospects for clinical trials, some already in early phases of implementation.