Quantitative assessments of the effects of a single exercise session on muscles in juvenile dermatomyositis
Quantitative assessments of the effects of a single exercise session on muscles in juvenile dermatomyositis
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DOI：
10.1002/art.21332
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发表时间：
2005-08-15
期刊：
影响因子：
--
通讯作者：
Murray, KJ
中科院分区：
文献类型：
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作者：
Maillard, SM;Jones, R;Murray, KJ
客观的。探讨运动对青少年皮肌炎（青少年 DM）儿童肌肉炎症的短期影响。使用磁共振成像 (MRI)、肌肉力量和血液参数作为结果测量。方法。对患有活动性青少年糖尿病、非活动性青少年糖尿病和健康儿童的肌肉力量（使用肌力测量）和功能以及 MRI T2 加权松弛时间测量进行评估；血液取自青少年糖尿病患者。完成了标准化的物理治疗主导的运动计划，随后立即进行了 MRI 检查。所有儿童在 30 分钟和 60 分钟时重新进行肌力测量和 MRI 评估，并在 60 分钟时对青少年 DM 患者进行重复血液检查。结果。 10 名患有活动性青少年糖尿病的儿童、10 名患有非活动性青少年糖尿病的儿童以及 20 名健康对照者完成了这项研究。在任何组中，无论是在运动计划后立即还是运动后 60 分钟内，通过 MRI、肌力测量和血液参数评估的肌肉炎症都没有因运动而发生显着变化。结论。在短期内，单次运动不会改变患有活动性或非活动性青少年糖尿病的儿童或健康儿童的肌肉炎症程度。数据表明，至少在这个时期，没有证据表明运动会增加肌肉内的炎症。因此，我们建议适度的运动计划对于青少年糖尿病儿童来说是安全的。
Objective. To investigate the short-term effects of exercise on muscle inflammation in children with juvenile dermatomyositis (juvenile DM). Magnetic resonance imaging (MRI), muscle strength, and blood parameters were used as outcome measures.Methods. Children with active juvenile DM, inactive juvenile DM, and healthy children were assessed for muscle strength (using myometry) and function, and MRI T2-weighted relaxation time measurement; blood was obtained from patients with juvenile DM. A standardized physiotherapy-led exercise program was completed, and the MRI was performed immediately afterwards. All children were reassessed with myometry and MRI at 30 minutes and 60 minutes, and repeat blood tests were performed at 60 minutes for the patients with juvenile DM.Results. Ten children with active juvenile DM, 10 with inactive juvenile DM, and 20 healthy controls completed the study. Muscle inflammation assessed by MRI, myometry, and blood parameters did not change significantly in response to exercise either immediately after or up to 60 minutes after the exercise program in any group.Conclusion. In the short term, a single bout of exercise does not change the degree of inflammation within the muscles of children with active or inactive juvenile DM or in healthy children. The data suggest that, at least in this time period, there is no evidence that exercise increases the inflammation within the muscles. We propose therefore that a moderate exercise program is safe for children with juvenile DM.