NUCLEAR MATRIX AND THE REGULATION OF GENE-EXPRESSION - TISSUE-SPECIFICITY
NUCLEAR MATRIX AND THE REGULATION OF GENE-EXPRESSION - TISSUE-SPECIFICITY
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DOI：
10.1002/jcb.240550105
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发表时间：
1994-05-01
影响因子：
4
通讯作者：
GETZENBERG, RH
中科院分区：
文献类型：
--
作者：
GETZENBERG, RH
单个转录因子或一组转录因子对基因表达的组织特异性调控不能简单地用DNA序列来解释。例如，在同一动物中，一种特定的转录因子能够与许多不同细胞类型的细胞核中的DNA相互作用，导致独特的基因表达，尽管所有细胞中存在相似的基因组。从历史上看，在同一动物的靶组织内，对单一类型因子的反应差异被认为是通过染色质结构的不同改变而发生的。最近，数据已经证明，激素和转录因子的组合一起工作，可以协同地在基因表达的调节中起作用[皮尔斯和Yamamoto（1993）：Science 259：1161-1165]。然而，这种组织特异性基因表达调控的分子机制仍然在很大程度上无法解释。目前的证据表明，在不同的细胞类型中，基因组的特定三维组织与细胞核的结构组分（核基质）之间的相互作用可能实现特定基因表达的调节。(C)1994 Wiley-Liss，Inc.
Tissue specific regulation of gene expression by a single transcription factor or group of transcription factors cannot be explained simply by DNA sequence alone. For example, in the same animal a particular transcription factor is capable of interacting with DNA in the nucleus of many different cell types, resulting in unique gene expressions despite the presence of a similar genome in all cells. Historically, these differences in response to a single type of factor within target tissues in the same animal have been suggested to occur through different alterations in chromatin structure. Recent, data has demonstrated that combinations of hormones and transcription factors working together may cooperatively play a role in the regulation of gene expression [Pearce and Yamamoto (1993): Science 259:1161-1165]. However, the molecular mechanisms of this tissue specific regulation of gene expression still remains largely unexplained. Current evidence suggests that in different cell types the interplay between the specific three-dimensional organization of the genome and the structural components of the nucleus, the nuclear matrix, may accomplish the regulation of specific gene expression. (C) 1994 Wiley-Liss, Inc.