Acutely elevated cortisol in response to stressor is associated with attentional bias toward depression-related stimuli but is not associated with attentional function
Acutely elevated cortisol in response to stressor is associated with attentional bias toward depression-related stimuli but is not associated with attentional function
复制标题
应激源引起的皮质醇急剧升高与对抑郁相关刺激的注意力偏向有关，但与注意力功能无关
DOI：
10.1007/s10484-011-9172-z
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发表时间：
2012
影响因子：
3
通讯作者：
H.
中科院分区：
文献类型：
--
作者：
Tsumura. H.;Shimada;H.
皮质醇诱导对负性刺激的注意偏向和注意功能受损。抑郁症患者的皮质醇水平较高，对抑郁相关刺激表现出注意力偏向，并损害了处理速度和执行注意力，这些都是注意力功能的组成部分。因此，该研究测试了以下假设：应激源引起的皮质醇急剧增加与对抑郁相关刺激的注意偏向以及受损的处理速度和执行注意力有关。36名被试在心算任务前后分别接受了点探测任务和连线测验A和B，测量了被试对抑郁相关刺激的注意偏向，并测量了被试的加工速度和执行注意。结果表明，只有在反应者中观察到对压力源后抑郁相关刺激的注意偏向（即，皮质醇升高的参与者）。另一方面，在反应者和非反应者之间，处理速度和执行注意力的表现没有差异。结果表明，急性皮质醇升高与注意偏向有关，但与加工速度和执行注意无关。研究结果对抑郁症的病因学有一定的启示。
Cortisol induces attentional bias toward a negative stimulus and impaired attentional function. Depressed individuals have high levels of cortisol, and exhibit an attentional bias toward a depression-related stimulus and impaired processing speed and executive attention, which are components of attentional function. Therefore, the study tested the hypotheses that an acute increase in cortisol in response to a stressor is associated with attentional bias toward a depression-related stimulus and impaired processing speed and executive attention. Thirty-six participants were administered the dot-probe task for the measurement of attentional bias toward a depression-related stimulus and the Trail Making Test A and B for the measurement of processing speed and executive attention before and after a mental arithmetic task. It was revealed that attentional bias toward a depression-related stimulus following the stressor was observed only among the responders (i.e., participants with cortisol elevation in response to a stressor). On the other hand, no differences in the performance of processing speed and executive attention were noted between the responders and non-responders. The results indicate that acutely elevated cortisol is related to attentional bias, but is not related to processing speed and executive attention. The results have an implication for the etiology of depression.