Mannose-binding lectin 2 gene and risk of adult glioma.
Mannose-binding lectin 2 gene and risk of adult glioma.
复制标题
甘露糖结合凝集素2基因和成人神经胶质瘤的风险。
DOI：
10.1371/journal.pone.0061117
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Parsa AT
中科院分区：
文献类型：
--
作者：
Michaud DS;Siddiq A;Cox DG;Backes DM;Calboli FC;Sughrue ME;Gaziano JM;Ma J;Stampfer M;Tworoger SS;Hunter DJ;Camargo CA Jr;Parsa AT
The immune system is likely to play a key role in the etiology of gliomas. Genetic polymorphisms in the mannose-binding lectin gene, a key activator in the lectin complement pathway, have been associated with risk of several cancers. To examine the role of the lectin complement pathway, we combined data from prospectively collected cohorts with available DNA specimens. Using a nested case-control design, we genotyped 85 single nucleotide polymorphisms (SNPs) in 9 genes in the lectin complement pathway and 3 additional SNPs in MBL2 were tested post hoc). Initial SNPs were selected using tagging SNPs for haplotypes; the second group of SNPs for MBL2 was selected based on functional SNPs related to phenotype. Associations were examined using logistic regression analysis. All statistical tests were two-sided. Nominal p-values are presented and are not corrected for multiple comparisons. A total of 143 glioma cases and 419 controls were available for this analysis. Statistically significant associations were observed for two SNPs in the mannose-binding lectin 2 (ML2) gene and risk of glioma (rs1982266 and rs1800450, test for trend p = 0.003 and p = 0.04, respectively, using the additive model). One of these SNPs, rs1800450, was associated with a 58% increase in glioma risk among those carrying one or two mutated alleles (odds ratio = 1.58, 95% confidence interval = 0.99–2.54), compared to those homozygous for the wild type allele. Overall, our findings suggest that MBL may play a role in the etiology of glioma. Future studies are needed to confirm these findings which may be due to chance, and if reproduced, to determine mechanisms that link glioma pathogenesis with the MBL complement pathway.
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影响因子：
30.8
作者：
Shete S;Hosking FJ;Robertson LB;Dobbins SE;Sanson M;Malmer B;Simon M;Marie Y;Boisselier B;Delattre JY;Hoang-Xuan K;El Hallani S;Idbaih A;Zelenika D;Andersson U;Henriksson R;Bergenheim AT;Feychting M;Lönn S;Ahlbom A;Schramm J;Linnebank M;Hemminki K;Kumar R;Hepworth SJ;Price A;Armstrong G;Liu Y;Gu X;Yu R;Lau C;Schoemaker M;Muir K;Swerdlow A;Lathrop M;Bondy M;Houlston RS
通讯作者：
Houlston RS
影响因子：
6.4
作者：
Baccarelli, Andrea;Hou, Lifang;Chow, Wong-Ho
通讯作者：
Chow, Wong-Ho
影响因子：
2.7
作者：
Segat, Ludovica;Crovella, Sergio;Campello, Cesare
通讯作者：
Campello, Cesare
DOI：
10.1084/jem.194.6.781
发表时间：
2001-09-17
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Ogden CA;deCathelineau A;Hoffmann PR;Bratton D;Ghebrehiwet B;Fadok VA;Henson PM
通讯作者：
Henson PM
影响因子：
4.4
作者：
Stuart, LM;Takahashi, K;Ezekowitz, RAB
通讯作者：
Ezekowitz, RAB